TY - JOUR
T1 - TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase
AU - van Eijk, Marco
AU - Scheij, Saskia S.
AU - van Roomen, Cindy P.A.A.
AU - Speijer, Dave
AU - Boot, Rolf G.
AU - Aerts, Johannes M.F.G.
PY - 2007/11/27
Y1 - 2007/11/27
N2 - Human chitotriosidase is specifically expressed by phagocytes, has anti-fungal activity towards chitin-containing fungi in vitro and in vivo, and is part of innate immunity. We studied the effect of toll-like receptor (TLR)- and nucleotide-binding oligomerization domain (NOD)-2 triggering on chitotriosidase expression and release by phagocytes. We find that TLR, but not NOD2 activation, regulates chitotriosidase release by neutrophils. Furthermore, both TLR and NOD2 activation resulted in diminished induction by monocytes. Lastly, NOD2 activation, but not TLR stimulation, induces chitinase expression in macrophages. We conclude that phagocyte-specific regulation is important for efficient eradication of chitin-containing pathogens.
AB - Human chitotriosidase is specifically expressed by phagocytes, has anti-fungal activity towards chitin-containing fungi in vitro and in vivo, and is part of innate immunity. We studied the effect of toll-like receptor (TLR)- and nucleotide-binding oligomerization domain (NOD)-2 triggering on chitotriosidase expression and release by phagocytes. We find that TLR, but not NOD2 activation, regulates chitotriosidase release by neutrophils. Furthermore, both TLR and NOD2 activation resulted in diminished induction by monocytes. Lastly, NOD2 activation, but not TLR stimulation, induces chitinase expression in macrophages. We conclude that phagocyte-specific regulation is important for efficient eradication of chitin-containing pathogens.
KW - Human
KW - Monocytes/Macrophages
KW - Neutrophils
UR - http://www.scopus.com/inward/record.url?scp=36048957925&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.febslet.2007.10.039
DO - https://doi.org/10.1016/j.febslet.2007.10.039
M3 - Article
C2 - 17976376
SN - 0014-5793
VL - 581
SP - 5389
EP - 5395
JO - FEBS letters
JF - FEBS letters
IS - 28
ER -