To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis

Jan Wnent; Ingvild Tjelmeland; Rolf Lefering; Rudolph W. Koster; Holger Maurer; Siobhán Masterson; Johan Herlitz; Bernd W. Böttiger; Fernando Rosell Ortiz; Gavin D. Perkins; Leo Bossaert; Maximilian Moertl; Pierre Mols; Irzal Hadžibegović; Anatolij Truhlář; Ari Salo; Valentine Baert; Eniko Nagy; Grzegorz Cebula; Violetta Raffay; Stefan Trenkler; Andrej Markota; Anneli Strömsöe; Jan-Thorsten Gräsner; Hajriz Alihodžić; Marios Ioannides; Mads Wissenberg; Josephine Escutnaire; Nikolaos Nikolaou; Bergthor Steinn Jonsson; Peter Wright; Federico Semeraro; Carlo Clarens; Steffie Beesems; Vitor H. Correia; Diana Cimpoesu; Roman Burkart; Scott Booth; Michael Baubin; Adolf Schinnerl; Gerhard Prause; Thomas Tschoellitsch; Helmut Trimmel; Rene Belz; Wolfgang Fleischmann; Magali Bartiaux; Koenraad Monsieurs; Stephan Wilmin; Mathias Faniel; Marie Vanhove; Pascale Lievens; Dominique Biarent; Marc van Nuffelen; Ives Hubloue; Jean-Marie Jacques; Michèle Yerna; Robert Leach; Mathieu Jeanmaire; Paule Denoël; Frank van Trimpont; Francis Desmet; Louise Delhaye; Vincent van Belleghem; Ken Dewitte; Musa Abbasi; Simon Scheyltjens; Olivier Vermylen; Diane de Longueville; Stéphane Debaize; Silvija Hunyadi Antičević; Slobodanka Keleuva; Milan Lazarević; Radmila Majhen Ujević; Gordana Antić Šego; Branka Bardak; Domagoj Mišković; Monika Praunová; Ondřej Franěk; Jaroslav Kratochvíl; Jan Přikryl; Roman Sýkora; Tomáš Vaňatka; Marek Vašák; Petr Jaššo; Petr Šmejkal; Otomar Kušička; Robin Šín; Eva Smržová; Dorián Pfeifer; Heini Harve-Rytsälä; Pamela Hiltunen; Peter Holmström; Timo Iirola; Katja Jokela; Hetti Kirves; Pekka Korvenoja; Markku Kuisma; Jukka Laine; Markus Lyyra; Sami Länkimäki; Petra Portaankorva; Lasse Raatiniemi; Marko Sainio; Piritta Setälä; Tuukka Toivonen; Jan Uotinen; Jukka Vaahersalo; Taneli Väyrynen; David Hamdan; Jean-Marc Agostinucci; Fabienne Branche; François Revaux; S. bastien Jonquet; Richard Loubert; Marion Boursier; Bruno Simonnet; Jean-Charles Morel; Steven Lagadec; Aurélie Avondo; Emilie Gelin; Emanuel Morel-Maréchal; C. cile Ursat; Laurent Villain-Coquet; Marc Fournier; Romain Tabary; Philippe le Pimpec; Delphine Hugenschmitt; Diego Abarrategui; Romain Blondet; Aurélie Arnaud; Sonia Sadoune; Julien Segard; Sophie Narcisse; M. lanie Laot; Thomas Pernot; Hubert Courcoux; Coralie Chassin; Benoît Jardel; Jeanne Picart; Franck Garden Brèche; Pierre-Alban Guenier; Renaud Getti; Alexandre Jeziorny; Antoine Leroy; Carine Vanderstraeten; S. bastien Dussoulier; Attila Haja; D. niel Németh; Andrea Válint; G. bor Csató; Gerda Lóczi; P. ter Vörös; Zsuzsanna Németh; Ferenc Molnár; Ferenc Nagy; Henrietta Kádár; Julia Duda; Justyna Tęczar; Sylwia Dul; Grażyna Świtacz; Andrzej Raczynski; Zlatko Fiser; Zlatko Babic; Aleksandra Opacic; Kornelija Jaksic Horvat; Snezana Vukelic; Jelena Tijanic; Dusan Milenkovic; Sasa Milic; Deze Babinski; Cedomir Boskovic; Jovanka Koprivica; Erika Terek; Goran Provci; Dragana Jovic Zvijer; Ľubica Bajerovská; Miroslav Chabroň; Danka Pražienková; Renáta Kratochvílová; Radoslav Burian; Martin Dobrík; Juraj Patráš; Vladimír Šteflík; Peter Androvič; František Mičáň; Božena Horáňová; J. lius Pavčo; Monika Grochová; T. ňa Bulíková; Rok Maček; Matej Rubelli Furman; Samo Podhostnik; Miha Oman; Klemen Lipovšek; Špela Baznik; Jurica Ferenčina; Matej Strnad; Edith Žižek; Miha Kodela; Alenka Antolinc Košat; Nina Lotrič; Jonny Lindqvist; Remy Stieglis; Anja Radstok

doi:https://doi.org/10.1016/j.resuscitation.2021.06.006

To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis

Jan Wnent, Ingvild Tjelmeland, Rolf Lefering, Rudolph W. Koster, Holger Maurer, Siobhán Masterson, Johan Herlitz, Bernd W. Böttiger, Fernando Rosell Ortiz, Gavin D. Perkins, Leo Bossaert, Maximilian Moertl, Pierre Mols, Irzal Hadžibegović, Anatolij Truhlář, Ari Salo, Valentine Baert, Eniko Nagy, Grzegorz Cebula, Violetta RaffayStefan Trenkler, Andrej Markota, Anneli Strömsöe, Jan-Thorsten Gräsner, Hajriz Alihodžić, Marios Ioannides, Mads Wissenberg, Josephine Escutnaire, Nikolaos Nikolaou, Bergthor Steinn Jonsson, Peter Wright, Federico Semeraro, Carlo Clarens, Steffie Beesems, Vitor H. Correia, Diana Cimpoesu, Roman Burkart, Scott Booth, Michael Baubin, Adolf Schinnerl, Gerhard Prause, Thomas Tschoellitsch, Helmut Trimmel, Rene Belz, Wolfgang Fleischmann, Magali Bartiaux, Koenraad Monsieurs, Stephan Wilmin, Mathias Faniel, Marie Vanhove, Pascale Lievens, Dominique Biarent, Marc van Nuffelen, Ives Hubloue, Jean-Marie Jacques, Michèle Yerna, Robert Leach, Mathieu Jeanmaire, Paule Denoël, Frank van Trimpont, Francis Desmet, Louise Delhaye, Vincent van Belleghem, Ken Dewitte, Musa Abbasi, Simon Scheyltjens, Olivier Vermylen, Diane de Longueville, Stéphane Debaize, Silvija Hunyadi Antičević, Slobodanka Keleuva, Milan Lazarević, Radmila Majhen Ujević, Gordana Antić Šego, Branka Bardak, Domagoj Mišković, Monika Praunová, Ondřej Franěk, Jaroslav Kratochvíl, Jan Přikryl, Roman Sýkora, Tomáš Vaňatka, Marek Vašák, Petr Jaššo, Petr Šmejkal, Otomar Kušička, Robin Šín, Eva Smržová, Dorián Pfeifer, Heini Harve-Rytsälä, Pamela Hiltunen, Peter Holmström, Timo Iirola, Katja Jokela, Hetti Kirves, Pekka Korvenoja, Markku Kuisma, Jukka Laine, Markus Lyyra, Sami Länkimäki, Petra Portaankorva, Lasse Raatiniemi, Marko Sainio, Piritta Setälä, Tuukka Toivonen, Jan Uotinen, Jukka Vaahersalo, Taneli Väyrynen, David Hamdan, Jean-Marc Agostinucci, Fabienne Branche, François Revaux, S. bastien Jonquet, Richard Loubert, Marion Boursier, Bruno Simonnet, Jean-Charles Morel, Steven Lagadec, Aurélie Avondo, Emilie Gelin, Emanuel Morel-Maréchal, C. cile Ursat, Laurent Villain-Coquet, Marc Fournier, Romain Tabary, Philippe le Pimpec, Delphine Hugenschmitt, Diego Abarrategui, Romain Blondet, Aurélie Arnaud, Sonia Sadoune, Julien Segard, Sophie Narcisse, M. lanie Laot, Thomas Pernot, Hubert Courcoux, Coralie Chassin, Benoît Jardel, Jeanne Picart, Franck Garden Brèche, Pierre-Alban Guenier, Renaud Getti, Alexandre Jeziorny, Antoine Leroy, Carine Vanderstraeten, S. bastien Dussoulier, Attila Haja, D. niel Németh, Andrea Válint, G. bor Csató, Gerda Lóczi, P. ter Vörös, Zsuzsanna Németh, Ferenc Molnár, Ferenc Nagy, Henrietta Kádár, Julia Duda, Justyna Tęczar, Sylwia Dul, Grażyna Świtacz, Andrzej Raczynski, Zlatko Fiser, Zlatko Babic, Aleksandra Opacic, Kornelija Jaksic Horvat, Snezana Vukelic, Jelena Tijanic, Dusan Milenkovic, Sasa Milic, Deze Babinski, Cedomir Boskovic, Jovanka Koprivica, Erika Terek, Goran Provci, Dragana Jovic Zvijer, Ľubica Bajerovská, Miroslav Chabroň, Danka Pražienková, Renáta Kratochvílová, Radoslav Burian, Martin Dobrík, Juraj Patráš, Vladimír Šteflík, Peter Androvič, František Mičáň, Božena Horáňová, J. lius Pavčo, Monika Grochová, T. ňa Bulíková, Rok Maček, Matej Rubelli Furman, Samo Podhostnik, Miha Oman, Klemen Lipovšek, Špela Baznik, Jurica Ferenčina, Matej Strnad, Edith Žižek, Miha Kodela, Alenka Antolinc Košat, Nina Lotrič, Jonny Lindqvist, Remy Stieglis, Anja Radstok

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Background: Survival after out-of-hospital cardiac arrest (OHCA) is still low. For every minute without resuscitation the likelihood of survival decreases. One critical step is initiation of immediate, high quality cardiopulmonary resuscitation (CPR). The aim of this subgroup analysis of data collected for the European Registry of Cardiac Arrest Study number 2 (EuReCa TWO) was to investigate the association between OHCA survival and two types of bystander CPR namely: chest compression only CPR (CConly) and CPR with chest compressions and ventilations (FullCPR). Method: In this subgroup analysis of EuReCa TWO, all patients who received bystander CPR were included. Outcomes were return of spontaneous circulation and survival to 30-days or hospital discharge. A multilevel binary logistic regression analysis with survival as the dependent variable was performed. Results: A total of 5884 patients were included in the analysis, varying between countries from 21 to 1444. Survival was 320 (8%) in the CConly group and 174 (13%) in the FullCPR group. After adjustment for age, sex, location, rhythm, cause, time to scene, witnessed collapse and country, patients who received FullCPR had a significantly higher survival rate when compared to those who received CConly (adjusted odds ration 1.46, 95% confidence interval 1.17–1.83). Conclusion: In this analysis, FullCPR was associated with higher survival compared to CConly. Guidelines should continue to emphasise the importance of compressions and ventilations during resuscitation for patients who suffer OHCA and CPR courses should continue to teach both.

Original language	English
Pages (from-to)	101-109
Number of pages	9
Journal	Resuscitation
Volume	166
Early online date	2021
DOIs	https://doi.org/10.1016/j.resuscitation.2021.06.006
Publication status	Published - Sept 2021

Keywords

Bystander CPR
Chest-compression only CPR
EuReCa
Full CPR
Out-of-hospital cardiac arrest

Access to Document

https://doi.org/10.1016/j.resuscitation.2021.06.006

Cite this

Wnent, J., Tjelmeland, I., Lefering, R., Koster, R. W., Maurer, H., Masterson, S., Herlitz, J., Böttiger, B. W., Ortiz, F. R., Perkins, G. D., Bossaert, L., Moertl, M., Mols, P., Hadžibegović, I., Truhlář, A., Salo, A., Baert, V., Nagy, E., Cebula, G., ... Radstok, A. (2021). To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis. Resuscitation, 166, 101-109. https://doi.org/10.1016/j.resuscitation.2021.06.006

@article{7e50b5d6ff984dd3abaca1e71576cd19,

title = "To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis",

abstract = "Background: Survival after out-of-hospital cardiac arrest (OHCA) is still low. For every minute without resuscitation the likelihood of survival decreases. One critical step is initiation of immediate, high quality cardiopulmonary resuscitation (CPR). The aim of this subgroup analysis of data collected for the European Registry of Cardiac Arrest Study number 2 (EuReCa TWO) was to investigate the association between OHCA survival and two types of bystander CPR namely: chest compression only CPR (CConly) and CPR with chest compressions and ventilations (FullCPR). Method: In this subgroup analysis of EuReCa TWO, all patients who received bystander CPR were included. Outcomes were return of spontaneous circulation and survival to 30-days or hospital discharge. A multilevel binary logistic regression analysis with survival as the dependent variable was performed. Results: A total of 5884 patients were included in the analysis, varying between countries from 21 to 1444. Survival was 320 (8%) in the CConly group and 174 (13%) in the FullCPR group. After adjustment for age, sex, location, rhythm, cause, time to scene, witnessed collapse and country, patients who received FullCPR had a significantly higher survival rate when compared to those who received CConly (adjusted odds ration 1.46, 95% confidence interval 1.17–1.83). Conclusion: In this analysis, FullCPR was associated with higher survival compared to CConly. Guidelines should continue to emphasise the importance of compressions and ventilations during resuscitation for patients who suffer OHCA and CPR courses should continue to teach both.",

keywords = "Bystander CPR, Chest-compression only CPR, EuReCa, Full CPR, Out-of-hospital cardiac arrest",

author = "Jan Wnent and Ingvild Tjelmeland and Rolf Lefering and Koster, {Rudolph W.} and Holger Maurer and Siobh{\'a}n Masterson and Johan Herlitz and B{\"o}ttiger, {Bernd W.} and Ortiz, {Fernando Rosell} and Perkins, {Gavin D.} and Leo Bossaert and Maximilian Moertl and Pierre Mols and Irzal Had{\v z}ibegovi{\'c} and Anatolij Truhl{\'a}{\v r} and Ari Salo and Valentine Baert and Eniko Nagy and Grzegorz Cebula and Violetta Raffay and Stefan Trenkler and Andrej Markota and Anneli Str{\"o}ms{\"o}e and Jan-Thorsten Gr{\"a}sner and Hajriz Alihod{\v z}i{\'c} and Marios Ioannides and Mads Wissenberg and Josephine Escutnaire and Nikolaos Nikolaou and Jonsson, {Bergthor Steinn} and Peter Wright and Federico Semeraro and Carlo Clarens and Steffie Beesems and Correia, {Vitor H.} and Diana Cimpoesu and Roman Burkart and Scott Booth and Michael Baubin and Adolf Schinnerl and Gerhard Prause and Thomas Tschoellitsch and Helmut Trimmel and Rene Belz and Wolfgang Fleischmann and Magali Bartiaux and Koenraad Monsieurs and Stephan Wilmin and Mathias Faniel and Marie Vanhove and Pascale Lievens and Dominique Biarent and {van Nuffelen}, Marc and Ives Hubloue and Jean-Marie Jacques and Mich{\`e}le Yerna and Robert Leach and Mathieu Jeanmaire and Paule Deno{\"e}l and {van Trimpont}, Frank and Francis Desmet and Louise Delhaye and {van Belleghem}, Vincent and Ken Dewitte and Musa Abbasi and Simon Scheyltjens and Olivier Vermylen and {de Longueville}, Diane and St{\'e}phane Debaize and Anti{\v c}evi{\'c}, {Silvija Hunyadi} and Slobodanka Keleuva and Milan Lazarevi{\'c} and Ujevi{\'c}, {Radmila Majhen} and {\v S}ego, {Gordana Anti{\'c}} and Branka Bardak and Domagoj Mi{\v s}kovi{\'c} and Monika Praunov{\'a} and Ond{\v r}ej Fran{\v e}k and Jaroslav Kratochv{\'i}l and Jan P{\v r}ikryl and Roman S{\'y}kora and Tom{\'a}{\v s} Va{\v n}atka and Marek Va{\v s}{\'a}k and Petr Ja{\v s}{\v s}o and Petr {\v S}mejkal and Otomar Ku{\v s}i{\v c}ka and Robin {\v S}{\'i}n and Eva Smr{\v z}ov{\'a} and Dori{\'a}n Pfeifer and Heini Harve-Ryts{\"a}l{\"a} and Pamela Hiltunen and Peter Holmstr{\"o}m and Timo Iirola and Katja Jokela and Hetti Kirves and Pekka Korvenoja and Markku Kuisma and Jukka Laine and Markus Lyyra and Sami L{\"a}nkim{\"a}ki and Petra Portaankorva and Lasse Raatiniemi and Marko Sainio and Piritta Set{\"a}l{\"a} and Tuukka Toivonen and Jan Uotinen and Jukka Vaahersalo and Taneli V{\"a}yrynen and David Hamdan and Jean-Marc Agostinucci and Fabienne Branche and Fran{\c c}ois Revaux and Jonquet, {S. bastien} and Richard Loubert and Marion Boursier and Bruno Simonnet and Jean-Charles Morel and Steven Lagadec and Aur{\'e}lie Avondo and Emilie Gelin and Emanuel Morel-Mar{\'e}chal and Ursat, {C. cile} and Laurent Villain-Coquet and Marc Fournier and Romain Tabary and {le Pimpec}, Philippe and Delphine Hugenschmitt and Diego Abarrategui and Romain Blondet and Aur{\'e}lie Arnaud and Sonia Sadoune and Julien Segard and Sophie Narcisse and Laot, {M. lanie} and Thomas Pernot and Hubert Courcoux and Coralie Chassin and Beno{\^i}t Jardel and Jeanne Picart and Br{\`e}che, {Franck Garden} and Pierre-Alban Guenier and Renaud Getti and Alexandre Jeziorny and Antoine Leroy and Carine Vanderstraeten and Dussoulier, {S. bastien} and Attila Haja and N{\'e}meth, {D. niel} and Andrea V{\'a}lint and Csat{\'o}, {G. bor} and Gerda L{\'o}czi and V{\"o}r{\"o}s, {P. ter} and Zsuzsanna N{\'e}meth and Ferenc Moln{\'a}r and Ferenc Nagy and Henrietta K{\'a}d{\'a}r and Julia Duda and Justyna T{\c e}czar and Sylwia Dul and Gra{\.z}yna {\'S}witacz and Andrzej Raczynski and Zlatko Fiser and Zlatko Babic and Aleksandra Opacic and Horvat, {Kornelija Jaksic} and Snezana Vukelic and Jelena Tijanic and Dusan Milenkovic and Sasa Milic and Deze Babinski and Cedomir Boskovic and Jovanka Koprivica and Erika Terek and Goran Provci and Zvijer, {Dragana Jovic} and {\v L}ubica Bajerovsk{\'a} and Miroslav Chabro{\v n} and Danka Pra{\v z}ienkov{\'a} and Ren{\'a}ta Kratochv{\'i}lov{\'a} and Radoslav Burian and Martin Dobr{\'i}k and Juraj Patr{\'a}{\v s} and Vladim{\'i}r {\v S}tefl{\'i}k and Peter Androvi{\v c} and Franti{\v s}ek Mi{\v c}{\'a}{\v n} and Bo{\v z}ena Hor{\'a}{\v n}ov{\'a} and Pav{\v c}o, {J. lius} and Monika Grochov{\'a} and Bul{\'i}kov{\'a}, {T. {\v n}a} and Rok Ma{\v c}ek and Furman, {Matej Rubelli} and Samo Podhostnik and Miha Oman and Klemen Lipov{\v s}ek and {\v S}pela Baznik and Jurica Feren{\v c}ina and Matej Strnad and Edith {\v Z}i{\v z}ek and Miha Kodela and Ko{\v s}at, {Alenka Antolinc} and Nina Lotri{\v c} and Jonny Lindqvist and Remy Stieglis and Anja Radstok",

note = "Funding Information: The EuReCa TWO study was funded by the European Resuscitation Council (ERC) and the national resuscitation registries and institutions conducting the study. The central database and meetings of the Study Management Team were funded by the German Resuscitation Registry . Funding organisations had no influence on the data analyses or preparation of the manuscript. The Study Management Team provided technical and administrative support. No additional funding was received for this subgroup analysis. Funding Information: AT, SM, AS, VR, HM, IT, IH, JH, EN, AS, PM, MM, AM, RL, FRO, LB, VB, ST, GC and JW have no conflicts of interest to declare. GP reports grants from Resuscitation Council UK , grants from British Heart Foundation , grants from National Institute for Health Research , other from European Resuscitation Council, outside the submitted work; and Editor, Resuscitation journal; International Liaison Committee on Resuscitation (Co-chair). Funding Information: RK reports grants, personal fees and non-financial support from Stryker Emergency care , personal fees from HeartSine , outside the submitted work. Funding Information: The EuReCa TWO study was funded by the European Resuscitation Council (ERC) and the national resuscitation registries and institutions conducting the study. The central database and meetings of the Study Management Team were funded by the German Resuscitation Registry. Funding organisations had no influence on the data analyses or preparation of the manuscript. The Study Management Team provided technical and administrative support. No additional funding was received for this subgroup analysis.AT, SM, AS, VR, HM, IT, IH, JH, EN, AS, PM, MM, AM, RL, FRO, LB, VB, ST, GC and JW have no conflicts of interest to declare. GP reports grants from Resuscitation Council UK, grants from British Heart Foundation, grants from National Institute for Health Research, other from European Resuscitation Council, outside the submitted work; and Editor, Resuscitation journal; International Liaison Committee on Resuscitation (Co-chair).JTG reports personal fees and other from Weinmann Emergency, personal fees and other from Philips Medical, personal fees and other from Fresenius, personal fees from Bard, personal fees and other from Zoll, outside the submitted work.RK reports grants, personal fees and non-financial support from Stryker Emergency care, personal fees from HeartSine, outside the submitted work.BWB reports personal fees from Philips GmbH DACH, personal fees from Novartis Pharma GmbH, personal fees from GS Elektromedizinische Ger?te G. Stemple GmbH, personal fees from C. R. Bard GmbH, personal reed from Forum f?r medizinische Fortbildung (FomF), personal fees from Zoll Medical Deutchland GmbH, personal fees from Boehringer Ingelheim Pharma GmbH & Co. KG, personal fees from Bayer Vital GmbH, personal fees from Baxalta Deutchland GmbH, outside the submitted work and Chairman of the German Resuscitation Council (GRC), Past Director of Science and Research of the European Resuscitation Council (ERC), Board Member of the German Interdisciplinary Association for Intensive and Emergency Medicin (DIVI), Member of the Advisory Board of the DIVI-Foundation Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = sep,

doi = "https://doi.org/10.1016/j.resuscitation.2021.06.006",

language = "English",

volume = "166",

pages = "101--109",

journal = "Resuscitation",

issn = "0300-9572",

publisher = "Elsevier Ireland Ltd",

}

Wnent, J, Tjelmeland, I, Lefering, R, Koster, RW, Maurer, H, Masterson, S, Herlitz, J, Böttiger, BW, Ortiz, FR, Perkins, GD, Bossaert, L, Moertl, M, Mols, P, Hadžibegović, I, Truhlář, A, Salo, A, Baert, V, Nagy, E, Cebula, G, Raffay, V, Trenkler, S, Markota, A, Strömsöe, A, Gräsner, J-T, Alihodžić, H, Ioannides, M, Wissenberg, M, Escutnaire, J, Nikolaou, N, Jonsson, BS, Wright, P, Semeraro, F, Clarens, C, Beesems, S, Correia, VH, Cimpoesu, D, Burkart, R, Booth, S, Baubin, M, Schinnerl, A, Prause, G, Tschoellitsch, T, Trimmel, H, Belz, R, Fleischmann, W, Bartiaux, M, Monsieurs, K, Wilmin, S, Faniel, M, Vanhove, M, Lievens, P, Biarent, D, van Nuffelen, M, Hubloue, I, Jacques, J-M, Yerna, M, Leach, R, Jeanmaire, M, Denoël, P, van Trimpont, F, Desmet, F, Delhaye, L, van Belleghem, V, Dewitte, K, Abbasi, M, Scheyltjens, S, Vermylen, O, de Longueville, D, Debaize, S, Antičević, SH, Keleuva, S, Lazarević, M, Ujević, RM, Šego, GA, Bardak, B, Mišković, D, Praunová, M, Franěk, O, Kratochvíl, J, Přikryl, J, Sýkora, R, Vaňatka, T, Vašák, M, Jaššo, P, Šmejkal, P, Kušička, O, Šín, R, Smržová, E, Pfeifer, D, Harve-Rytsälä, H, Hiltunen, P, Holmström, P, Iirola, T, Jokela, K, Kirves, H, Korvenoja, P, Kuisma, M, Laine, J, Lyyra, M, Länkimäki, S, Portaankorva, P, Raatiniemi, L, Sainio, M, Setälä, P, Toivonen, T, Uotinen, J, Vaahersalo, J, Väyrynen, T, Hamdan, D, Agostinucci, J-M, Branche, F, Revaux, F, Jonquet, SB, Loubert, R, Boursier, M, Simonnet, B, Morel, J-C, Lagadec, S, Avondo, A, Gelin, E, Morel-Maréchal, E, Ursat, CC, Villain-Coquet, L, Fournier, M, Tabary, R, le Pimpec, P, Hugenschmitt, D, Abarrategui, D, Blondet, R, Arnaud, A, Sadoune, S, Segard, J, Narcisse, S, Laot, ML, Pernot, T, Courcoux, H, Chassin, C, Jardel, B, Picart, J, Brèche, FG, Guenier, P-A, Getti, R, Jeziorny, A, Leroy, A, Vanderstraeten, C, Dussoulier, SB, Haja, A, Németh, DN, Válint, A, Csató, GB, Lóczi, G, Vörös, PT, Németh, Z, Molnár, F, Nagy, F, Kádár, H, Duda, J, Tęczar, J, Dul, S, Świtacz, G, Raczynski, A, Fiser, Z, Babic, Z, Opacic, A, Horvat, KJ, Vukelic, S, Tijanic, J, Milenkovic, D, Milic, S, Babinski, D, Boskovic, C, Koprivica, J, Terek, E, Provci, G, Zvijer, DJ, Bajerovská, Ľ, Chabroň, M, Pražienková, D, Kratochvílová, R, Burian, R, Dobrík, M, Patráš, J, Šteflík, V, Androvič, P, Mičáň, F, Horáňová, B, Pavčo, JL, Grochová, M, Bulíková, TŇ, Maček, R, Furman, MR, Podhostnik, S, Oman, M, Lipovšek, K, Baznik, Š, Ferenčina, J, Strnad, M, Žižek, E, Kodela, M, Košat, AA, Lotrič, N, Lindqvist, J, Stieglis, R & Radstok, A 2021, 'To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis', Resuscitation, vol. 166, pp. 101-109. https://doi.org/10.1016/j.resuscitation.2021.06.006

TY - JOUR

T1 - To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis

AU - Wnent, Jan

AU - Tjelmeland, Ingvild

AU - Lefering, Rolf

AU - Koster, Rudolph W.

AU - Maurer, Holger

AU - Masterson, Siobhán

AU - Herlitz, Johan

AU - Böttiger, Bernd W.

AU - Ortiz, Fernando Rosell

AU - Perkins, Gavin D.

AU - Bossaert, Leo

AU - Moertl, Maximilian

AU - Mols, Pierre

AU - Hadžibegović, Irzal

AU - Truhlář, Anatolij

AU - Salo, Ari

AU - Baert, Valentine

AU - Nagy, Eniko

AU - Cebula, Grzegorz

AU - Raffay, Violetta

AU - Trenkler, Stefan

AU - Markota, Andrej

AU - Strömsöe, Anneli

AU - Gräsner, Jan-Thorsten

AU - Alihodžić, Hajriz

AU - Ioannides, Marios

AU - Wissenberg, Mads

AU - Escutnaire, Josephine

AU - Nikolaou, Nikolaos

AU - Jonsson, Bergthor Steinn

AU - Wright, Peter

AU - Semeraro, Federico

AU - Clarens, Carlo

AU - Beesems, Steffie

AU - Correia, Vitor H.

AU - Cimpoesu, Diana

AU - Burkart, Roman

AU - Booth, Scott

AU - Baubin, Michael

AU - Schinnerl, Adolf

AU - Prause, Gerhard

AU - Tschoellitsch, Thomas

AU - Trimmel, Helmut

AU - Belz, Rene

AU - Fleischmann, Wolfgang

AU - Bartiaux, Magali

AU - Monsieurs, Koenraad

AU - Wilmin, Stephan

AU - Faniel, Mathias

AU - Vanhove, Marie

AU - Lievens, Pascale

AU - Biarent, Dominique

AU - van Nuffelen, Marc

AU - Hubloue, Ives

AU - Jacques, Jean-Marie

AU - Yerna, Michèle

AU - Leach, Robert

AU - Jeanmaire, Mathieu

AU - Denoël, Paule

AU - van Trimpont, Frank

AU - Desmet, Francis

AU - Delhaye, Louise

AU - van Belleghem, Vincent

AU - Dewitte, Ken

AU - Abbasi, Musa

AU - Scheyltjens, Simon

AU - Vermylen, Olivier

AU - de Longueville, Diane

AU - Debaize, Stéphane

AU - Antičević, Silvija Hunyadi

AU - Keleuva, Slobodanka

AU - Lazarević, Milan

AU - Ujević, Radmila Majhen

AU - Šego, Gordana Antić

AU - Bardak, Branka

AU - Mišković, Domagoj

AU - Praunová, Monika

AU - Franěk, Ondřej

AU - Kratochvíl, Jaroslav

AU - Přikryl, Jan

AU - Sýkora, Roman

AU - Vaňatka, Tomáš

AU - Vašák, Marek

AU - Jaššo, Petr

AU - Šmejkal, Petr

AU - Kušička, Otomar

AU - Šín, Robin

AU - Smržová, Eva

AU - Pfeifer, Dorián

AU - Harve-Rytsälä, Heini

AU - Hiltunen, Pamela

AU - Holmström, Peter

AU - Iirola, Timo

AU - Jokela, Katja

AU - Kirves, Hetti

AU - Korvenoja, Pekka

AU - Kuisma, Markku

AU - Laine, Jukka

AU - Lyyra, Markus

AU - Länkimäki, Sami

AU - Portaankorva, Petra

AU - Raatiniemi, Lasse

AU - Sainio, Marko

AU - Setälä, Piritta

AU - Toivonen, Tuukka

AU - Uotinen, Jan

AU - Vaahersalo, Jukka

AU - Väyrynen, Taneli

AU - Hamdan, David

AU - Agostinucci, Jean-Marc

AU - Branche, Fabienne

AU - Revaux, François

AU - Jonquet, S. bastien

AU - Loubert, Richard

AU - Boursier, Marion

AU - Simonnet, Bruno

AU - Morel, Jean-Charles

AU - Lagadec, Steven

AU - Avondo, Aurélie

AU - Gelin, Emilie

AU - Morel-Maréchal, Emanuel

AU - Ursat, C. cile

AU - Villain-Coquet, Laurent

AU - Fournier, Marc

AU - Tabary, Romain

AU - le Pimpec, Philippe

AU - Hugenschmitt, Delphine

AU - Abarrategui, Diego

AU - Blondet, Romain

AU - Arnaud, Aurélie

AU - Sadoune, Sonia

AU - Segard, Julien

AU - Narcisse, Sophie

AU - Laot, M. lanie

AU - Pernot, Thomas

AU - Courcoux, Hubert

AU - Chassin, Coralie

AU - Jardel, Benoît

AU - Picart, Jeanne

AU - Brèche, Franck Garden

AU - Guenier, Pierre-Alban

AU - Getti, Renaud

AU - Jeziorny, Alexandre

AU - Leroy, Antoine

AU - Vanderstraeten, Carine

AU - Dussoulier, S. bastien

AU - Haja, Attila

AU - Németh, D. niel

AU - Válint, Andrea

AU - Csató, G. bor

AU - Lóczi, Gerda

AU - Vörös, P. ter

AU - Németh, Zsuzsanna

AU - Molnár, Ferenc

AU - Nagy, Ferenc

AU - Kádár, Henrietta

AU - Duda, Julia

AU - Tęczar, Justyna

AU - Dul, Sylwia

AU - Świtacz, Grażyna

AU - Raczynski, Andrzej

AU - Fiser, Zlatko

AU - Babic, Zlatko

AU - Opacic, Aleksandra

AU - Horvat, Kornelija Jaksic

AU - Vukelic, Snezana

AU - Tijanic, Jelena

AU - Milenkovic, Dusan

AU - Milic, Sasa

AU - Babinski, Deze

AU - Boskovic, Cedomir

AU - Koprivica, Jovanka

AU - Terek, Erika

AU - Provci, Goran

AU - Zvijer, Dragana Jovic

AU - Bajerovská, Ľubica

AU - Chabroň, Miroslav

AU - Pražienková, Danka

AU - Kratochvílová, Renáta

AU - Burian, Radoslav

AU - Dobrík, Martin

AU - Patráš, Juraj

AU - Šteflík, Vladimír

AU - Androvič, Peter

AU - Mičáň, František

AU - Horáňová, Božena

AU - Pavčo, J. lius

AU - Grochová, Monika

AU - Bulíková, T. ňa

AU - Maček, Rok

AU - Furman, Matej Rubelli

AU - Podhostnik, Samo

AU - Oman, Miha

AU - Lipovšek, Klemen

AU - Baznik, Špela

AU - Ferenčina, Jurica

AU - Strnad, Matej

AU - Žižek, Edith

AU - Kodela, Miha

AU - Košat, Alenka Antolinc

AU - Lotrič, Nina

AU - Lindqvist, Jonny

AU - Stieglis, Remy

AU - Radstok, Anja

N1 - Funding Information: The EuReCa TWO study was funded by the European Resuscitation Council (ERC) and the national resuscitation registries and institutions conducting the study. The central database and meetings of the Study Management Team were funded by the German Resuscitation Registry . Funding organisations had no influence on the data analyses or preparation of the manuscript. The Study Management Team provided technical and administrative support. No additional funding was received for this subgroup analysis. Funding Information: AT, SM, AS, VR, HM, IT, IH, JH, EN, AS, PM, MM, AM, RL, FRO, LB, VB, ST, GC and JW have no conflicts of interest to declare. GP reports grants from Resuscitation Council UK , grants from British Heart Foundation , grants from National Institute for Health Research , other from European Resuscitation Council, outside the submitted work; and Editor, Resuscitation journal; International Liaison Committee on Resuscitation (Co-chair). Funding Information: RK reports grants, personal fees and non-financial support from Stryker Emergency care , personal fees from HeartSine , outside the submitted work. Funding Information: The EuReCa TWO study was funded by the European Resuscitation Council (ERC) and the national resuscitation registries and institutions conducting the study. The central database and meetings of the Study Management Team were funded by the German Resuscitation Registry. Funding organisations had no influence on the data analyses or preparation of the manuscript. The Study Management Team provided technical and administrative support. No additional funding was received for this subgroup analysis.AT, SM, AS, VR, HM, IT, IH, JH, EN, AS, PM, MM, AM, RL, FRO, LB, VB, ST, GC and JW have no conflicts of interest to declare. GP reports grants from Resuscitation Council UK, grants from British Heart Foundation, grants from National Institute for Health Research, other from European Resuscitation Council, outside the submitted work; and Editor, Resuscitation journal; International Liaison Committee on Resuscitation (Co-chair).JTG reports personal fees and other from Weinmann Emergency, personal fees and other from Philips Medical, personal fees and other from Fresenius, personal fees from Bard, personal fees and other from Zoll, outside the submitted work.RK reports grants, personal fees and non-financial support from Stryker Emergency care, personal fees from HeartSine, outside the submitted work.BWB reports personal fees from Philips GmbH DACH, personal fees from Novartis Pharma GmbH, personal fees from GS Elektromedizinische Ger?te G. Stemple GmbH, personal fees from C. R. Bard GmbH, personal reed from Forum f?r medizinische Fortbildung (FomF), personal fees from Zoll Medical Deutchland GmbH, personal fees from Boehringer Ingelheim Pharma GmbH & Co. KG, personal fees from Bayer Vital GmbH, personal fees from Baxalta Deutchland GmbH, outside the submitted work and Chairman of the German Resuscitation Council (GRC), Past Director of Science and Research of the European Resuscitation Council (ERC), Board Member of the German Interdisciplinary Association for Intensive and Emergency Medicin (DIVI), Member of the Advisory Board of the DIVI-Foundation Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/9

Y1 - 2021/9

N2 - Background: Survival after out-of-hospital cardiac arrest (OHCA) is still low. For every minute without resuscitation the likelihood of survival decreases. One critical step is initiation of immediate, high quality cardiopulmonary resuscitation (CPR). The aim of this subgroup analysis of data collected for the European Registry of Cardiac Arrest Study number 2 (EuReCa TWO) was to investigate the association between OHCA survival and two types of bystander CPR namely: chest compression only CPR (CConly) and CPR with chest compressions and ventilations (FullCPR). Method: In this subgroup analysis of EuReCa TWO, all patients who received bystander CPR were included. Outcomes were return of spontaneous circulation and survival to 30-days or hospital discharge. A multilevel binary logistic regression analysis with survival as the dependent variable was performed. Results: A total of 5884 patients were included in the analysis, varying between countries from 21 to 1444. Survival was 320 (8%) in the CConly group and 174 (13%) in the FullCPR group. After adjustment for age, sex, location, rhythm, cause, time to scene, witnessed collapse and country, patients who received FullCPR had a significantly higher survival rate when compared to those who received CConly (adjusted odds ration 1.46, 95% confidence interval 1.17–1.83). Conclusion: In this analysis, FullCPR was associated with higher survival compared to CConly. Guidelines should continue to emphasise the importance of compressions and ventilations during resuscitation for patients who suffer OHCA and CPR courses should continue to teach both.

AB - Background: Survival after out-of-hospital cardiac arrest (OHCA) is still low. For every minute without resuscitation the likelihood of survival decreases. One critical step is initiation of immediate, high quality cardiopulmonary resuscitation (CPR). The aim of this subgroup analysis of data collected for the European Registry of Cardiac Arrest Study number 2 (EuReCa TWO) was to investigate the association between OHCA survival and two types of bystander CPR namely: chest compression only CPR (CConly) and CPR with chest compressions and ventilations (FullCPR). Method: In this subgroup analysis of EuReCa TWO, all patients who received bystander CPR were included. Outcomes were return of spontaneous circulation and survival to 30-days or hospital discharge. A multilevel binary logistic regression analysis with survival as the dependent variable was performed. Results: A total of 5884 patients were included in the analysis, varying between countries from 21 to 1444. Survival was 320 (8%) in the CConly group and 174 (13%) in the FullCPR group. After adjustment for age, sex, location, rhythm, cause, time to scene, witnessed collapse and country, patients who received FullCPR had a significantly higher survival rate when compared to those who received CConly (adjusted odds ration 1.46, 95% confidence interval 1.17–1.83). Conclusion: In this analysis, FullCPR was associated with higher survival compared to CConly. Guidelines should continue to emphasise the importance of compressions and ventilations during resuscitation for patients who suffer OHCA and CPR courses should continue to teach both.

KW - Bystander CPR

KW - Chest-compression only CPR

KW - EuReCa

KW - Full CPR

KW - Out-of-hospital cardiac arrest

UR - http://www.scopus.com/inward/record.url?scp=85109428244&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.resuscitation.2021.06.006

DO - https://doi.org/10.1016/j.resuscitation.2021.06.006

M3 - Article

C2 - 34146622

SN - 0300-9572

VL - 166

SP - 101

EP - 109

JO - Resuscitation

JF - Resuscitation

ER -

To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis

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