Abstract

We present the case of a 15-year-old girl, with a fifth cystic progression of an adamantinomatous craniopharyngioma after multiple surgeries and previous local radiotherapy. She had severe visual impairment, panhypopituitarism including diabetes insipidus, and several components of hypothalamic damage, including morbid obesity and severe fatigue. To prevent further late effects hampering her quality of survival, she was treated biweekly with intravenous tocilizumab, an anti-interleukin-6 agent, which stabilized the cyst for a prolonged time. Based on the biology of adamantinomatous craniopharyngioma, this immune-modulating treatment seems promising for the treatment of this cystic tumor in order to reduce surgery and delay or omit radiotherapy.
Original languageEnglish
Article number1225734
JournalFrontiers in Endocrinology
Volume14
DOIs
Publication statusPublished - 2023

Keywords

  • adamantinomatous craniopharyngioma
  • case report
  • cyst
  • hypothalamus
  • tocilizumab
  • visual impairment

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