TY - JOUR
T1 - Toward development of imesenchymal stem cells for immunomodulatory therapy
AU - De Witte, Samantha F.H.
AU - Franquesa, Marcella
AU - Baan, Carla C.
AU - Hoogduijn, Martin J.
N1 - Publisher Copyright: © 2016 de Witte, Franquesa, Baan and Hoogduijn.
PY - 2016
Y1 - 2016
N2 - Mesenchymal stem cells (MSC) are under development as an immunomodulatory therapy. The anticipated immunomodulatory effects of MSC are broad, from direct inhibition of lymphocyte proliferation, induction of regulatory T and B cells, to resetting the immune system via a hit-and-run principle. There are endless flavors of MSC. Differences between MSC are originating from donors variation, differences in tissue of origin, the effects of culture conditions, and expansion time. Even standard culture conditions change the properties of MSC dramatically and generate MSC that only remotely resemble their in vivo counterparts. Adjustments in culture protocols can further emphasize properties of interest in MSC, thereby generating cells fitted for specific purposes. Culture improved immunomodulatory MSC can be designed to target particular immune disorders. In this review, we describe the observed and the desired immunomodulatory effects of MSC and propose approaches how MSC with optimal immunomodulatory properties can be developed.
AB - Mesenchymal stem cells (MSC) are under development as an immunomodulatory therapy. The anticipated immunomodulatory effects of MSC are broad, from direct inhibition of lymphocyte proliferation, induction of regulatory T and B cells, to resetting the immune system via a hit-and-run principle. There are endless flavors of MSC. Differences between MSC are originating from donors variation, differences in tissue of origin, the effects of culture conditions, and expansion time. Even standard culture conditions change the properties of MSC dramatically and generate MSC that only remotely resemble their in vivo counterparts. Adjustments in culture protocols can further emphasize properties of interest in MSC, thereby generating cells fitted for specific purposes. Culture improved immunomodulatory MSC can be designed to target particular immune disorders. In this review, we describe the observed and the desired immunomodulatory effects of MSC and propose approaches how MSC with optimal immunomodulatory properties can be developed.
KW - Cell therapy
KW - Immunomodulation
KW - Mesenchymal stem cell
KW - Optimization
KW - Secretome
UR - http://www.scopus.com/inward/record.url?scp=84958206619&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fimmu.2015.00648
DO - https://doi.org/10.3389/fimmu.2015.00648
M3 - Review article
SN - 1664-3224
VL - 6
JO - Frontiers in immunology
JF - Frontiers in immunology
IS - JAN
M1 - 648
ER -