TY - JOUR
T1 - Toxicokinetics of a dipyridamole (Persantin) intoxication: case report
AU - Lagas, Jurjen S.
AU - Wilhelm, Abraham J.
AU - Vos, René M.
AU - van den Dool, Erik-Jan
AU - van der Heide, Yvonne
AU - Huissoon, Sandra
AU - Beijnen, Jos H.
AU - Brandjes, Desiderius P. M.
PY - 2011
Y1 - 2011
N2 - We report a case of a 51-year-old woman who was admitted to the hospital after ingestion of large doses of dipyridamole (12 g), temazepam (1 g) and oxazepam (0.2 g) with suicidal intent. The highest dipyridamole concentration that was measured in serum was 9.2 mg/L, which was paralleled by impaired platelet activation. For temazepam and oxazepam, peak serum concentrations were 8.5 and 1.3 mg/L, respectively. The patient was treated with activated charcoal, magnesium sulfate and aminophylline and could be discharged in good physical condition within 17 hours. This is the first report that provides toxicokinetic data and a corresponding pharmacodynamic effect after an intoxication with dipyridamole
AB - We report a case of a 51-year-old woman who was admitted to the hospital after ingestion of large doses of dipyridamole (12 g), temazepam (1 g) and oxazepam (0.2 g) with suicidal intent. The highest dipyridamole concentration that was measured in serum was 9.2 mg/L, which was paralleled by impaired platelet activation. For temazepam and oxazepam, peak serum concentrations were 8.5 and 1.3 mg/L, respectively. The patient was treated with activated charcoal, magnesium sulfate and aminophylline and could be discharged in good physical condition within 17 hours. This is the first report that provides toxicokinetic data and a corresponding pharmacodynamic effect after an intoxication with dipyridamole
U2 - https://doi.org/10.1177/0960327110368696
DO - https://doi.org/10.1177/0960327110368696
M3 - Article
C2 - 20375123
SN - 0960-3271
VL - 30
SP - 74
EP - 78
JO - Human & experimental toxicology
JF - Human & experimental toxicology
IS - 1
ER -