Toxicokinetics of a dipyridamole (Persantin) intoxication: case report

Jurjen S. Lagas, Abraham J. Wilhelm, René M. Vos, Erik-Jan van den Dool, Yvonne van der Heide, Sandra Huissoon, Jos H. Beijnen, Desiderius P. M. Brandjes

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We report a case of a 51-year-old woman who was admitted to the hospital after ingestion of large doses of dipyridamole (12 g), temazepam (1 g) and oxazepam (0.2 g) with suicidal intent. The highest dipyridamole concentration that was measured in serum was 9.2 mg/L, which was paralleled by impaired platelet activation. For temazepam and oxazepam, peak serum concentrations were 8.5 and 1.3 mg/L, respectively. The patient was treated with activated charcoal, magnesium sulfate and aminophylline and could be discharged in good physical condition within 17 hours. This is the first report that provides toxicokinetic data and a corresponding pharmacodynamic effect after an intoxication with dipyridamole
Original languageEnglish
Pages (from-to)74-78
JournalHuman & experimental toxicology
Issue number1
Publication statusPublished - 2011

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