TY - CHAP
T1 - Tracer Kinetic Modelling
AU - Lammertsma, Adriaan A.
PY - 2020/10/20
Y1 - 2020/10/20
N2 - This chapter provides an overview of the basic principles of quantification of cerebral PET studies using compartmental modelling. Both single-and two-tissue compartment models are presented with emphasis on volume of distribution and non-displaceable binding potential as outcome measures. Next, both full and simplified reference tissue models are introduced, obviating the need for arterial cannulation. Finally, a brief overview is given of various parametric methods enabling calculations at a voxel level.
AB - This chapter provides an overview of the basic principles of quantification of cerebral PET studies using compartmental modelling. Both single-and two-tissue compartment models are presented with emphasis on volume of distribution and non-displaceable binding potential as outcome measures. Next, both full and simplified reference tissue models are introduced, obviating the need for arterial cannulation. Finally, a brief overview is given of various parametric methods enabling calculations at a voxel level.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148680613&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36407814
U2 - https://doi.org/10.1007/978-3-030-53168-3_2
DO - https://doi.org/10.1007/978-3-030-53168-3_2
M3 - Chapter
C2 - 36407814
SN - 9783030531676
T3 - PET and SPECT in Neurology
SP - 37
EP - 52
BT - PET and SPECT in Neurology
PB - Springer International Publishing
ER -