TY - JOUR
T1 - Trans-diagnostic comparison of response inhibition in Tourette’s disorder and obsessive-compulsive disorder
AU - Fan, Siyan
AU - Cath, Danielle C.
AU - van der Werf, Ysbrand D.
AU - de Wit, Stella
AU - Veltman, Dick J.
AU - van den Heuvel, Odile A.
PY - 2018/10/3
Y1 - 2018/10/3
N2 - Objectives: Impaired response inhibition is related to neurodevelopmental disorders, such as Tourette’s disorder (TD) and obsessive-compulsive disorder (OCD). Unlike OCD, in which neural correlates of response inhibition have been extensively studied, TD literature is limited. By using a Stop-Signal task, we investigated the neural mechanisms underlying response inhibition deficits in TD compared to OCD and healthy controls (HCs). Methods: Twenty-three TD patients, 20 OCD patients and 22 HCs were scanned (3T MRI). Region-of-interest analyses were performed between TD, OCD and HCs. Results: Performance was similar across all subject groups. During inhibition TD compared with HCs showed higher right inferior parietal cortex (IPC) activation. During error processing TD compared with HCs showed hyperactivity in the left cerebellum, right mesencephalon, and right insula. Three-group comparison showed an effect of group for error-related activation in the supplementary motor area (SMA). Post-hoc analyses showed higher error-related SMA activity in TD compared with OCD and HCs. Error-related left cerebellar activity correlated positively with tic severity. Conclusions: Hyperactivation of IPC during inhibition and a widespread hyperactivated network during error processing in TD suggest compensatory inhibition- and error-related circuit recruitment to boost task performance. The lack of overlap with activation pattern in OCD suggests such compensatory mechanism is TD-specific.
AB - Objectives: Impaired response inhibition is related to neurodevelopmental disorders, such as Tourette’s disorder (TD) and obsessive-compulsive disorder (OCD). Unlike OCD, in which neural correlates of response inhibition have been extensively studied, TD literature is limited. By using a Stop-Signal task, we investigated the neural mechanisms underlying response inhibition deficits in TD compared to OCD and healthy controls (HCs). Methods: Twenty-three TD patients, 20 OCD patients and 22 HCs were scanned (3T MRI). Region-of-interest analyses were performed between TD, OCD and HCs. Results: Performance was similar across all subject groups. During inhibition TD compared with HCs showed higher right inferior parietal cortex (IPC) activation. During error processing TD compared with HCs showed hyperactivity in the left cerebellum, right mesencephalon, and right insula. Three-group comparison showed an effect of group for error-related activation in the supplementary motor area (SMA). Post-hoc analyses showed higher error-related SMA activity in TD compared with OCD and HCs. Error-related left cerebellar activity correlated positively with tic severity. Conclusions: Hyperactivation of IPC during inhibition and a widespread hyperactivated network during error processing in TD suggest compensatory inhibition- and error-related circuit recruitment to boost task performance. The lack of overlap with activation pattern in OCD suggests such compensatory mechanism is TD-specific.
KW - Stop-Signal task
KW - Tourette’s disorder
KW - error process
KW - obsessive-compulsive disorder
KW - response inhibition
UR - http://www.scopus.com/inward/record.url?scp=85025829644&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/15622975.2017.1347711
DO - https://doi.org/10.1080/15622975.2017.1347711
M3 - Article
C2 - 28741401
SN - 1562-2975
VL - 19
SP - 527
EP - 537
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
IS - 7
ER -