TY - JOUR
T1 - Transcriptional profile of the human peripheral nervous system by serial analysis of gene expression
AU - de Jonge, Rosalein R.
AU - Vreijling, Jeroen P.
AU - Meintjes, Asker
AU - Kwa, Marcel S. G.
AU - van Kampen, A. H. C.
AU - van Schaik, Ivo N.
AU - Baas, Frank
PY - 2003
Y1 - 2003
N2 - The peripheral nerve contains both nonmyelinating and myelinating Schwann cells. The interactions between axons, surrounding myelin, and Schwarm cells are thought to be important for the correct functioning of the nervous system. To get insight into the genes involved in human myelination and maintenance of the myelin sheath and nerve, we performed a serial analysis of gene expression of human sciatic nerve and cultured Schwann cells. In the sciatic nerve library, we found high expression of genes encoding proteins related to lipid metabolism, the complement system, and the cell cycle, while cultured Schwann cells showed mainly high expression of genes encoding extracellular matrix proteins. The results of our study will assist in the identification of genes involved in maintenance of myelin and peripheral nerve and of genes involved in inherited peripheral neuropathies. (C) 2003 Elsevier Science (USA). All rights reserved
AB - The peripheral nerve contains both nonmyelinating and myelinating Schwann cells. The interactions between axons, surrounding myelin, and Schwarm cells are thought to be important for the correct functioning of the nervous system. To get insight into the genes involved in human myelination and maintenance of the myelin sheath and nerve, we performed a serial analysis of gene expression of human sciatic nerve and cultured Schwann cells. In the sciatic nerve library, we found high expression of genes encoding proteins related to lipid metabolism, the complement system, and the cell cycle, while cultured Schwann cells showed mainly high expression of genes encoding extracellular matrix proteins. The results of our study will assist in the identification of genes involved in maintenance of myelin and peripheral nerve and of genes involved in inherited peripheral neuropathies. (C) 2003 Elsevier Science (USA). All rights reserved
U2 - https://doi.org/10.1016/S0888-7543(03)00124-1
DO - https://doi.org/10.1016/S0888-7543(03)00124-1
M3 - Article
C2 - 12837261
SN - 0888-7543
VL - 82
SP - 97
EP - 108
JO - Genomics
JF - Genomics
IS - 2
ER -