TY - CHAP
T1 - Transfusion-Associated Circulatory Overload
AU - Klanderman, Robert B.
AU - Vlaar, Alexander P. J.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Transfusion-associated circulatory overload (TACO) is almost as old as transfusion itself. Patients suffered ‘cardiac embarrassment’ with evidence of pulmonary oedema, which today is classified as TACO. TACO is the most common cause of transfusion-related major morbidity and mortality, surpassing transfusion-related acute lung injury (TRALI) by 2010 according to UK haemovigilance data. Primary risk factors for developing TACO include the extremes of age, a positive fluid balance, preexisting renal disease and myocardial dysfunction, number of units transfused and speed of transfusion. The differential diagnosis is dependent on the presenting symptom, time of onset, progression of symptoms as well as their severity. In TACO the goals of treatment include first supportive care for respiratory symptoms, and second treatment of circulatory overload. Respiratory symptoms in the absence of pulmonary oedema, or those that do not meet diagnostic criteria of either TACO or TRALI, point to TAD.
AB - Transfusion-associated circulatory overload (TACO) is almost as old as transfusion itself. Patients suffered ‘cardiac embarrassment’ with evidence of pulmonary oedema, which today is classified as TACO. TACO is the most common cause of transfusion-related major morbidity and mortality, surpassing transfusion-related acute lung injury (TRALI) by 2010 according to UK haemovigilance data. Primary risk factors for developing TACO include the extremes of age, a positive fluid balance, preexisting renal disease and myocardial dysfunction, number of units transfused and speed of transfusion. The differential diagnosis is dependent on the presenting symptom, time of onset, progression of symptoms as well as their severity. In TACO the goals of treatment include first supportive care for respiratory symptoms, and second treatment of circulatory overload. Respiratory symptoms in the absence of pulmonary oedema, or those that do not meet diagnostic criteria of either TACO or TRALI, point to TAD.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85151679880&origin=inward
U2 - https://doi.org/10.1002/9781119665885.ch10
DO - https://doi.org/10.1002/9781119665885.ch10
M3 - Chapter
SN - 9781119665816
T3 - Practical Transfusion Medicine: Sixth Edition
SP - 120
EP - 129
BT - Practical Transfusion Medicine: Sixth Edition
PB - Wiley
ER -