Transient neonatal myelosuppression after fetal exposure to maternal chemotherapy. Case report and review of the literature

F.E.A. Udink ten Cate; C.H. ten Hove; W.M.L.E. Nix; J.I. de Vries; A.A. van de Loosdrecht; R.M. van Elburg

doi:https://doi.org/10.1159/000151759

Transient neonatal myelosuppression after fetal exposure to maternal chemotherapy. Case report and review of the literature

F.E.A. Udink ten Cate, C.H. ten Hove, W.M.L.E. Nix, J.I. de Vries, A.A. van de Loosdrecht, R.M. van Elburg

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

Transient neonatal myelosuppression (TNM) is a rare but potentially life-threatening adverse effect of fetal exposure to maternal chemotherapy during pregnancy. We report a case of TNM in a preterm infant born to a mother diagnosed with acute lymphoblastic leukemia during pregnancy. The mother received chemotherapy during the second and third trimester. The neonate was successfully treated with supportive care. In addition, we also conducted a medical literature review and identified another 14 cases of TNM. Although the long-term outcome of these children is not known, short-term survival is relatively good. Prompt recognition and aggressive treatment of infants at risk for TNM is mandatory. Copyright © 2008 S. Karger AG.

Original language	English
Pages (from-to)	80-85
Journal	Neonatology
Volume	95
Issue number	1
DOIs	https://doi.org/10.1159/000151759
Publication status	Published - 2009

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https://doi.org/10.1159/000151759

Cite this

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title = "Transient neonatal myelosuppression after fetal exposure to maternal chemotherapy. Case report and review of the literature",

abstract = "Transient neonatal myelosuppression (TNM) is a rare but potentially life-threatening adverse effect of fetal exposure to maternal chemotherapy during pregnancy. We report a case of TNM in a preterm infant born to a mother diagnosed with acute lymphoblastic leukemia during pregnancy. The mother received chemotherapy during the second and third trimester. The neonate was successfully treated with supportive care. In addition, we also conducted a medical literature review and identified another 14 cases of TNM. Although the long-term outcome of these children is not known, short-term survival is relatively good. Prompt recognition and aggressive treatment of infants at risk for TNM is mandatory. Copyright {\textcopyright} 2008 S. Karger AG.",

author = "{Udink ten Cate}, F.E.A. and {ten Hove}, C.H. and W.M.L.E. Nix and {de Vries}, J.I. and {van de Loosdrecht}, A.A. and {van Elburg}, R.M.",

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AU - Udink ten Cate, F.E.A.

AU - ten Hove, C.H.

AU - Nix, W.M.L.E.

AU - de Vries, J.I.

AU - van de Loosdrecht, A.A.

AU - van Elburg, R.M.

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AB - Transient neonatal myelosuppression (TNM) is a rare but potentially life-threatening adverse effect of fetal exposure to maternal chemotherapy during pregnancy. We report a case of TNM in a preterm infant born to a mother diagnosed with acute lymphoblastic leukemia during pregnancy. The mother received chemotherapy during the second and third trimester. The neonate was successfully treated with supportive care. In addition, we also conducted a medical literature review and identified another 14 cases of TNM. Although the long-term outcome of these children is not known, short-term survival is relatively good. Prompt recognition and aggressive treatment of infants at risk for TNM is mandatory. Copyright © 2008 S. Karger AG.

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