Transient Parvovirus B19 DNAemia after Kidney Transplantation: A 2-Sided Story

Anne Russcher; Marijke Molenaar-De Backer; Caroline de Brouwer; Kyra Dijkstra; Jesper Kers; Aiko de Vries; Hans Zaaijer; Ann Vossen; Aloysius Kroes

doi:https://doi.org/10.1093/ofid/ofad079

Transient Parvovirus B19 DNAemia after Kidney Transplantation: A 2-Sided Story

Anne Russcher, Marijke Molenaar-De Backer, Caroline de Brouwer, Kyra Dijkstra, Jesper Kers, Aiko de Vries, Hans Zaaijer, Ann Vossen, Aloysius Kroes

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Parvovirus B19 (B19V) DNAemia appears to be a relatively common finding after kidney transplantation. However, not all DNAemia signifies active infection with replicating virus. This study screened 134 patients posttransplantation for B19V DNAemia and identified 2 cases in which viral DNA was present after transplantation, with the donor kidney as probable source of the DNA. In both cases intact viral particles could not be detected using an endonuclease method, indicating the presence of noninfectious DNA remnants.

Original language	English
Article number	ofad079
Journal	Open forum infectious diseases
Volume	10
Issue number	3
DOIs	https://doi.org/10.1093/ofid/ofad079
Publication status	Published - 1 Mar 2023

Keywords

DNAemia
kidney transplantation
parvovirus B19
viral activity
viremia

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https://doi.org/10.1093/ofid/ofad079

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title = "Transient Parvovirus B19 DNAemia after Kidney Transplantation: A 2-Sided Story",

abstract = "Parvovirus B19 (B19V) DNAemia appears to be a relatively common finding after kidney transplantation. However, not all DNAemia signifies active infection with replicating virus. This study screened 134 patients posttransplantation for B19V DNAemia and identified 2 cases in which viral DNA was present after transplantation, with the donor kidney as probable source of the DNA. In both cases intact viral particles could not be detected using an endonuclease method, indicating the presence of noninfectious DNA remnants.",

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note = "Funding Information: We thank Dr I. Bajema of the Department of Pathology for providing the kidney biopsies for PCR testing and Dr E. Wessels for facilitating PCR testing on the biopsies. Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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AU - Russcher, Anne

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AU - Dijkstra, Kyra

AU - Kers, Jesper

AU - de Vries, Aiko

AU - Zaaijer, Hans

AU - Vossen, Ann

AU - Kroes, Aloysius

N1 - Funding Information: We thank Dr I. Bajema of the Department of Pathology for providing the kidney biopsies for PCR testing and Dr E. Wessels for facilitating PCR testing on the biopsies. Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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N2 - Parvovirus B19 (B19V) DNAemia appears to be a relatively common finding after kidney transplantation. However, not all DNAemia signifies active infection with replicating virus. This study screened 134 patients posttransplantation for B19V DNAemia and identified 2 cases in which viral DNA was present after transplantation, with the donor kidney as probable source of the DNA. In both cases intact viral particles could not be detected using an endonuclease method, indicating the presence of noninfectious DNA remnants.

AB - Parvovirus B19 (B19V) DNAemia appears to be a relatively common finding after kidney transplantation. However, not all DNAemia signifies active infection with replicating virus. This study screened 134 patients posttransplantation for B19V DNAemia and identified 2 cases in which viral DNA was present after transplantation, with the donor kidney as probable source of the DNA. In both cases intact viral particles could not be detected using an endonuclease method, indicating the presence of noninfectious DNA remnants.

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Transient Parvovirus B19 DNAemia after Kidney Transplantation: A 2-Sided Story

Abstract

Keywords

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