TY - JOUR
T1 - Transition of endometrial stromal sarcoma into high-grade sarcoma
AU - Amant, Frederic
AU - Woestenborghs, Heidi
AU - Vandenbroucke, Vanessa
AU - Berteloot, Patrick
AU - Neven, Patrick
AU - Moerman, Philippe
AU - Vergote, Ignace
PY - 2006
Y1 - 2006
N2 - Endometrial stromal sarcoma typically is of low grade and hormone-sensitive. Although these characteristics result in an indolent behavior, little data are available on the evolution over time. We report on two cases where microscopic and immunohistochemic assessment of the tumor on several occasions during 8 and 25 years of follow up enabled us to document a transition of a low-grade into a high-grade malignancy. These were mainly characterized by increased cellular atypia, absence of spiral arterioles and an increased mitotic index and proliferation index (MIB1). Since this transition was related to clinical loss of hormone sensitivity, the therapeutic approach consisting of hormonal treatment in combination with repetitive surgery was switched to chemotherapy only. These long-term follow up data provide insight in endometrial stromal sarcoma tumor biology and highlight the importance of sampling recurrent tumors to estimate biologic behavior in order to tailor subsequent treatment
AB - Endometrial stromal sarcoma typically is of low grade and hormone-sensitive. Although these characteristics result in an indolent behavior, little data are available on the evolution over time. We report on two cases where microscopic and immunohistochemic assessment of the tumor on several occasions during 8 and 25 years of follow up enabled us to document a transition of a low-grade into a high-grade malignancy. These were mainly characterized by increased cellular atypia, absence of spiral arterioles and an increased mitotic index and proliferation index (MIB1). Since this transition was related to clinical loss of hormone sensitivity, the therapeutic approach consisting of hormonal treatment in combination with repetitive surgery was switched to chemotherapy only. These long-term follow up data provide insight in endometrial stromal sarcoma tumor biology and highlight the importance of sampling recurrent tumors to estimate biologic behavior in order to tailor subsequent treatment
U2 - https://doi.org/10.1016/j.ygyno.2006.07.013
DO - https://doi.org/10.1016/j.ygyno.2006.07.013
M3 - Article
C2 - 16919712
SN - 0090-8258
VL - 103
SP - 1137
EP - 1140
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -