TY - JOUR
T1 - Transmission of anelloviruses to HIV-1 infected children
AU - Kaczorowska, Joanna
AU - Cicilionytė, Aurelija
AU - Wahdaty, Annet Firouzi
AU - Deijs, Martin
AU - Jebbink, Maarten F.
AU - Bakker, Margreet
AU - van der Hoek, Lia
N1 - Funding Information: This work was supported by The National Natural Science Foundation of China (NO. 22076138) and Tianjin Science and Technology planning project (NO. 21JCYBJC01750). Funding Information: This study was supported by a grant from the European Union’s Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie agreement No. 721367 (HONOURs) and Amsterdam University Medical Center funding connected to HONOURs. Publisher Copyright: Copyright © 2022 Kaczorowska, Cicilionytė, Wahdaty, Deijs, Jebbink, Bakker and van der Hoek.
PY - 2022/9/16
Y1 - 2022/9/16
N2 - Anelloviruses (AVs) are widespread in the population and infect humans at the early stage of life. The mode of transmission of AVs is still unknown, however, mother-to-child transmission, e.g., via breastfeeding, is one of the likely infection routes. To determine whether the mother-to-child transmission of AVs may still occur despite the absence of natural birth and breastfeeding, 29 serum samples from five HIV-1-positive mother and child pairs were Illumina-sequenced. The Illumina reads were mapped to an AV lineage database “Anellometrix” containing 502 distinct ORF1 sequences. Although the majority of lineages from the mother were not shared with the child, the mother and child anellomes did display a significant similarity. These findings suggest that AVs may be transmitted from mothers to their children via different routes than delivery or breastfeeding.
AB - Anelloviruses (AVs) are widespread in the population and infect humans at the early stage of life. The mode of transmission of AVs is still unknown, however, mother-to-child transmission, e.g., via breastfeeding, is one of the likely infection routes. To determine whether the mother-to-child transmission of AVs may still occur despite the absence of natural birth and breastfeeding, 29 serum samples from five HIV-1-positive mother and child pairs were Illumina-sequenced. The Illumina reads were mapped to an AV lineage database “Anellometrix” containing 502 distinct ORF1 sequences. Although the majority of lineages from the mother were not shared with the child, the mother and child anellomes did display a significant similarity. These findings suggest that AVs may be transmitted from mothers to their children via different routes than delivery or breastfeeding.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139214760&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36187966
U2 - https://doi.org/10.3389/fmicb.2022.951040
DO - https://doi.org/10.3389/fmicb.2022.951040
M3 - Article
C2 - 36187966
SN - 1664-302X
VL - 13
SP - 951040
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 951040
ER -