TY - JOUR
T1 - Transplantability of Human Head and Neck Squamous Cell Carcinomas in Athymic Nude Mice
AU - Braakhuis, Boudewijn J.M.
AU - Laarman, Dick A.W.
AU - Nauta, Jos J.P.
AU - Van Walsum, Marijke
AU - Van Dongen, Guus A.M.S.
AU - Snow, Gordon B.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Tumor material from 91 patients with squamous cell carcinoma of the head and neck was transplanted subcutaneously in athymic nude mice. In the first (man to mouse) passage, the calculated mean probability of tumor take in a single mouse was 11%. The probability of growth in the first passage was significantly better for moderately and poorly differentiated tumors than for well-differentiated tumors. Also, the implantation of lymph node material resulted in a significantly better tumor take rate than material taken from a primary tumor. Transplantability was not dependent on the following characteristics: localization, T or N stage of the tumor, or the sex of the patients. Once growth was established, all variables studied had no influence on the probability of growth in the subsequent mouse passages. A relationship between tumor growth in nude mice and patient prognosis could not be found. When transplanting head and neck squamous cell carcinoma in nude mice, it has to be recognized that some tumor characteristics will influence the success of tumor growth.
AB - Tumor material from 91 patients with squamous cell carcinoma of the head and neck was transplanted subcutaneously in athymic nude mice. In the first (man to mouse) passage, the calculated mean probability of tumor take in a single mouse was 11%. The probability of growth in the first passage was significantly better for moderately and poorly differentiated tumors than for well-differentiated tumors. Also, the implantation of lymph node material resulted in a significantly better tumor take rate than material taken from a primary tumor. Transplantability was not dependent on the following characteristics: localization, T or N stage of the tumor, or the sex of the patients. Once growth was established, all variables studied had no influence on the probability of growth in the subsequent mouse passages. A relationship between tumor growth in nude mice and patient prognosis could not be found. When transplanting head and neck squamous cell carcinoma in nude mice, it has to be recognized that some tumor characteristics will influence the success of tumor growth.
UR - http://www.scopus.com/inward/record.url?scp=0024439058&partnerID=8YFLogxK
U2 - https://doi.org/10.1001/archotol.1989.01860330066018
DO - https://doi.org/10.1001/archotol.1989.01860330066018
M3 - Article
C2 - 2765223
SN - 0886-4470
VL - 115
SP - 1076
EP - 1078
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 9
ER -