TY - JOUR
T1 - Traumatic muscle injury
AU - Edouard, Pascal
AU - Reurink, Gustaaf
AU - Mackey, Abigail L.
AU - Lieber, Richard L.
AU - Pizzari, Tania
AU - Järvinen, Tero A. H.
AU - Gronwald, Thomas
AU - Hollander, Karsten
N1 - Funding Information: P.E. reports received funding from the French Research Agency for research on muscle injuries in the context of the FULGUR project (ANR-19-STPH-003) in the perspective of the Paris 2024 Olympic and Paralympic Games. G.R. reports an institutional grant from Arthrex for a previously performed randomized clinical trial on the efficacy of PRP in hamstring injuries and non-financial support to his institution from Arthrex (Heittich centrifuge on loan) for a previously performed randomized clinical trial on the efficacy of PRP in ankle osteoarthritis. The other authors declare no competing interests. Publisher Copyright: © 2023, Springer Nature Limited.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Traumatic muscle injury represents a collection of skeletal muscle pathologies caused by trauma to the muscle tissue and is defined as damage to the muscle tissue that can result in a functional deficit. Traumatic muscle injury can affect people across the lifespan and can result from high stresses and strains to skeletal muscle tissue, often due to muscle activation while the muscle is lengthening, resulting in indirect and non-contact muscle injuries (strains or ruptures), or from external impact, resulting in direct muscle injuries (contusion or laceration). At a microscopic level, muscle fibres can repair focal damage but must be completely regenerated after full myofibre necrosis. The diagnosis of muscle injury is based on patient history and physical examination. Imaging may be indicated to eliminate differential diagnoses. The management of muscle injury has changed within the past 5 years from initial rest, immobilization and (over)protection to early activation and progressive loading using an active approach. One challenge of muscle injury management is that numerous medical treatment options, such as medications and injections, are often used or proposed to try to accelerate muscle recovery despite very limited efficacy evidence. Another challenge is the prevention of muscle injury owing to the multifactorial and complex nature of this injury.
AB - Traumatic muscle injury represents a collection of skeletal muscle pathologies caused by trauma to the muscle tissue and is defined as damage to the muscle tissue that can result in a functional deficit. Traumatic muscle injury can affect people across the lifespan and can result from high stresses and strains to skeletal muscle tissue, often due to muscle activation while the muscle is lengthening, resulting in indirect and non-contact muscle injuries (strains or ruptures), or from external impact, resulting in direct muscle injuries (contusion or laceration). At a microscopic level, muscle fibres can repair focal damage but must be completely regenerated after full myofibre necrosis. The diagnosis of muscle injury is based on patient history and physical examination. Imaging may be indicated to eliminate differential diagnoses. The management of muscle injury has changed within the past 5 years from initial rest, immobilization and (over)protection to early activation and progressive loading using an active approach. One challenge of muscle injury management is that numerous medical treatment options, such as medications and injections, are often used or proposed to try to accelerate muscle recovery despite very limited efficacy evidence. Another challenge is the prevention of muscle injury owing to the multifactorial and complex nature of this injury.
UR - http://www.scopus.com/inward/record.url?scp=85174498653&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41572-023-00469-8
DO - https://doi.org/10.1038/s41572-023-00469-8
M3 - Article
C2 - 37857686
SN - 2056-676X
VL - 9
JO - NATURE REVIEWS DISEASE PRIMERS
JF - NATURE REVIEWS DISEASE PRIMERS
IS - 1
M1 - 56
ER -