Treatment of therapy-resistant perineal metastatic Crohn's disease after proctectomy using anti-tumor necrosis factor chimeric monoclonal antibody, cA2: report of two cases

H. M. van Dullemen; E. de Jong; F. Slors; G. N. Tytgat; S. J. van Deventer

doi:https://doi.org/10.1007/BF02236903

Treatment of therapy-resistant perineal metastatic Crohn's disease after proctectomy using anti-tumor necrosis factor chimeric monoclonal antibody, cA2: report of two cases

H. M. van Dullemen, E. de Jong, F. Slors, G. N. Tytgat, S. J. van Deventer

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Two young females with well-documented Crohn's disease and nonhealing perineal wounds following proctectomy compatible with "metastatic Crohn's disease" are described. We hypothesized that metastatic Crohn's disease would be a tumor necrosis factor-dependent inflammatory reaction and have treated these two patients with the anti-tumor necrosis factor chimeric monoclonal antibody, cA2. Administration of cA2 was followed by a rapid reduction of subjective and objective parameters of inflammation and caused a substantial reduction of the wound size. These preliminary data are consistent with a tumor necrosis factor-dependent inflammatory cause of Crohn's disease and its extraintestinal manifestations and provide support for targeting tumor necrosis factor in this condition

Original language	English
Pages (from-to)	98-102
Journal	Diseases of the colon and rectum
Volume	41
Issue number	1
DOIs	https://doi.org/10.1007/BF02236903
Publication status	Published - 1998

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https://doi.org/10.1007/BF02236903

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@article{c2c8a326619c4656a9d32446b4456b5a,

title = "Treatment of therapy-resistant perineal metastatic Crohn's disease after proctectomy using anti-tumor necrosis factor chimeric monoclonal antibody, cA2: report of two cases",

abstract = "Two young females with well-documented Crohn's disease and nonhealing perineal wounds following proctectomy compatible with {"}metastatic Crohn's disease{"} are described. We hypothesized that metastatic Crohn's disease would be a tumor necrosis factor-dependent inflammatory reaction and have treated these two patients with the anti-tumor necrosis factor chimeric monoclonal antibody, cA2. Administration of cA2 was followed by a rapid reduction of subjective and objective parameters of inflammation and caused a substantial reduction of the wound size. These preliminary data are consistent with a tumor necrosis factor-dependent inflammatory cause of Crohn's disease and its extraintestinal manifestations and provide support for targeting tumor necrosis factor in this condition",

author = "{van Dullemen}, {H. M.} and {de Jong}, E. and F. Slors and Tytgat, {G. N.} and {van Deventer}, {S. J.}",

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pages = "98--102",

journal = "Diseases of the colon and rectum",

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Treatment of therapy-resistant perineal metastatic Crohn's disease after proctectomy using anti-tumor necrosis factor chimeric monoclonal antibody, cA2: report of two cases. / van Dullemen, H. M.; de Jong, E.; Slors, F. et al.
In: Diseases of the colon and rectum, Vol. 41, No. 1, 1998, p. 98-102.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Treatment of therapy-resistant perineal metastatic Crohn's disease after proctectomy using anti-tumor necrosis factor chimeric monoclonal antibody, cA2: report of two cases

AU - van Dullemen, H. M.

AU - de Jong, E.

AU - Slors, F.

AU - Tytgat, G. N.

AU - van Deventer, S. J.

PY - 1998

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AB - Two young females with well-documented Crohn's disease and nonhealing perineal wounds following proctectomy compatible with "metastatic Crohn's disease" are described. We hypothesized that metastatic Crohn's disease would be a tumor necrosis factor-dependent inflammatory reaction and have treated these two patients with the anti-tumor necrosis factor chimeric monoclonal antibody, cA2. Administration of cA2 was followed by a rapid reduction of subjective and objective parameters of inflammation and caused a substantial reduction of the wound size. These preliminary data are consistent with a tumor necrosis factor-dependent inflammatory cause of Crohn's disease and its extraintestinal manifestations and provide support for targeting tumor necrosis factor in this condition

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DO - https://doi.org/10.1007/BF02236903

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