TY - JOUR
T1 - Treatment Outcome of Children with Retinoblastoma in a Tertiary Care Referral Hospital in Indonesia
AU - Handayani, Krisna
AU - Indraswari, Braghmandita W.
AU - Sitaresmi, Mei N.
AU - Mulatsih, Sri
AU - Widjajanto, Pudjo H.
AU - Kors, Wijnanda A.
AU - Kaspers, Gertjan Jl
AU - Mostert, Saskia
N1 - Funding Information: We are most grateful to the mother of the patient described in the case report. We are also thankful for the support received from the Noord-Zuid Programma and AFAS Foundation. Funding Statement Our study was supported by the Noord-Zuid Programma and AFAS Foundation. Publisher Copyright: © 2021. All Rights Reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - BACKGROUND: Although survival rates for retinoblastoma (RB) are over 95% in high-income countries, its high mortality rate in low and middle-income countries remains a great concern. Few studies investigated treatment outcome and factors contributing to RB survival in these latter settings. Aims of this study are to determine treatment outcome of Indonesian children diagnosed with RB and to explore factors predictive of treatment outcome. METHODS: This study was a retrospective medical records review combined with an illustrative case report. Children newly diagnosed with RB between January 2011 and December 2016 at a tertiary care referral hospital in Indonesia were included. A home visit was conducted to perform an in-depth interview with a mother of two children affected by RB. RESULTS: Of all 61 children with RB, 39% abandoned treatment, 21% died, 20% had progressive or relapsed disease and 20% event-free survival. Progressive or relapsed disease was more common in older (2 years at diagnosis, 29%) than young (.
AB - BACKGROUND: Although survival rates for retinoblastoma (RB) are over 95% in high-income countries, its high mortality rate in low and middle-income countries remains a great concern. Few studies investigated treatment outcome and factors contributing to RB survival in these latter settings. Aims of this study are to determine treatment outcome of Indonesian children diagnosed with RB and to explore factors predictive of treatment outcome. METHODS: This study was a retrospective medical records review combined with an illustrative case report. Children newly diagnosed with RB between January 2011 and December 2016 at a tertiary care referral hospital in Indonesia were included. A home visit was conducted to perform an in-depth interview with a mother of two children affected by RB. RESULTS: Of all 61 children with RB, 39% abandoned treatment, 21% died, 20% had progressive or relapsed disease and 20% event-free survival. Progressive or relapsed disease was more common in older (2 years at diagnosis, 29%) than young (.
KW - Retinoblastoma- treatment outcome- low and middle-income countries
UR - http://www.scopus.com/inward/record.url?scp=85107252047&partnerID=8YFLogxK
U2 - https://doi.org/10.31557/APJCP.2021.22.5.1613
DO - https://doi.org/10.31557/APJCP.2021.22.5.1613
M3 - Article
C2 - 34048193
SN - 2476-762X
VL - 22
SP - 1613
EP - 1621
JO - Asian Pacific journal of cancer prevention : APJCP
JF - Asian Pacific journal of cancer prevention : APJCP
IS - 5
ER -