TY - JOUR
T1 - Tropical pyomyositis: an update
AU - Shittu, Adebayo
AU - Deinhardt-Emmer, Stefanie
AU - Vas Nunes, Jonathan
AU - Niemann, Silke
AU - Grobusch, Martin P.
AU - Schaumburg, Frieder
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Tropical pyomyositis (TP) is a life-threatening bacterial infection of the skeletal muscle that occurs particularly among children, young adults and those with immunocompromised conditions. The appropriate diagnosis and treatment are often delayed due to its non-specific signs, leading to fatal consequences. Staphylococcus aureus, especially methicillin-susceptible S. aureus, is responsible for most TP cases. However, other bacteria (i.e. streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Candida spp., Mycobacterium spp.) have been reported. This narrative review provides an update on the epidemiology and clinical course of TP. A special focus is laid on the role of toxins (i.e. Panton-Valentine Leucocidin and α-toxin) in the pathogenesis of TP and their implication for the clinical management of infection.
AB - Tropical pyomyositis (TP) is a life-threatening bacterial infection of the skeletal muscle that occurs particularly among children, young adults and those with immunocompromised conditions. The appropriate diagnosis and treatment are often delayed due to its non-specific signs, leading to fatal consequences. Staphylococcus aureus, especially methicillin-susceptible S. aureus, is responsible for most TP cases. However, other bacteria (i.e. streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Candida spp., Mycobacterium spp.) have been reported. This narrative review provides an update on the epidemiology and clinical course of TP. A special focus is laid on the role of toxins (i.e. Panton-Valentine Leucocidin and α-toxin) in the pathogenesis of TP and their implication for the clinical management of infection.
KW - Staphylococcus aureus
KW - clinical course
KW - epidemiology
KW - pathogenesis
KW - review
KW - tropical pyomyositis
UR - http://www.scopus.com/inward/record.url?scp=85083513795&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/tmi.13395
DO - https://doi.org/10.1111/tmi.13395
M3 - Review article
C2 - 32219926
SN - 1360-2276
VL - 25
SP - 660
EP - 665
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
IS - 6
ER -