TY - JOUR
T1 - Tubal flushing with oil-based or water-based contrast at hysterosalpingography for infertility
T2 - long-term reproductive outcomes of a randomized trial
AU - van Rijswijk, Joukje
AU - van Welie, Nienke
AU - Dreyer, Kim
AU - Pham, Clarabelle T
AU - Verhoeve, Harold R
AU - Hoek, Annemieke
AU - de Bruin, Jan Peter
AU - Nap, Annemiek W
AU - van Hooff, Machiel H A
AU - Goddijn, Mariëtte
AU - Hooker, Angelo B
AU - Bourdrez, Petra
AU - van Dongen, Angelique J C M
AU - van Rooij, Ilse A J
AU - van Rijnsaardt-Lukassen, Henrike G M
AU - van Golde, Ron J T
AU - van Heteren, Cathelijne F
AU - Pelinck, Marie J
AU - Duijn, Annette E J
AU - Kaplan, Mesrure
AU - Lambalk, Cornelis B
AU - Mijatovic, Velja
AU - Mol, Ben W J
N1 - Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - OBJECTIVE: To determine the impact of oil-based versus water-based contrast on pregnancy and live birth rates ≤5 years after hysterosalpingography (HSG) in infertile women.DESIGN: A 5-year follow-up study of a multicenter randomized trial.SETTING: Hospitals.PATIENT(S): Infertile women with an ovulatory cycle, 18-39 years of age, and having a low risk of tubal pathology.INTERVENTION(S): Use of oil-based versus water-based contrast during HSG.MAIN OUTCOME MEASURE(S): Ongoing pregnancy, live births, time to ongoing pregnancy, second ongoing pregnancy.RESULT(S): A total of 1,119 women were randomly assigned to HSG with oil-based contrast (n = 557) or water-based contrast (n = 562). After 5 years, 444 of 555 women in the oil group (80.0%) and 419 of 559 women in the water group (75.0%) had an ongoing pregnancy (relative risk [RR] 1.07; 95% confidence interval [CI] 1.00-1.14), and 415 of 555 women in the oil group (74.8%) and 376 of 559 women in the water group (67.3%) had live births (RR 1.11; 95% CI 1.03-1.20). In the oil group, 228 pregnancies (41.1%) were conceived naturally versus 194 (34.7%) pregnancies in the water group (RR 1.18; 95% CI 1.02-1.38). The time to ongoing pregnancy was significantly shorter in the oil group versus the water group (10.0 vs. 13.7 months; hazard ratio, 1.25; 95% CI 1.09-1.43). No difference was found in the occurrence of a second ongoing pregnancy.CONCLUSION(S): During a 5-year time frame, ongoing pregnancy and live birth rates are higher after tubal flushing with oil-based contrast during HSG compared with water-based contrast. More pregnancies are naturally conceived and time to ongoing pregnancy is shorter after HSG with oil-based contrast.CLINICAL TRIAL REGISTRATION NUMBER: Netherlands Trial Register (NTR) 3270 and NTR6577(www.trialregister.nl).
AB - OBJECTIVE: To determine the impact of oil-based versus water-based contrast on pregnancy and live birth rates ≤5 years after hysterosalpingography (HSG) in infertile women.DESIGN: A 5-year follow-up study of a multicenter randomized trial.SETTING: Hospitals.PATIENT(S): Infertile women with an ovulatory cycle, 18-39 years of age, and having a low risk of tubal pathology.INTERVENTION(S): Use of oil-based versus water-based contrast during HSG.MAIN OUTCOME MEASURE(S): Ongoing pregnancy, live births, time to ongoing pregnancy, second ongoing pregnancy.RESULT(S): A total of 1,119 women were randomly assigned to HSG with oil-based contrast (n = 557) or water-based contrast (n = 562). After 5 years, 444 of 555 women in the oil group (80.0%) and 419 of 559 women in the water group (75.0%) had an ongoing pregnancy (relative risk [RR] 1.07; 95% confidence interval [CI] 1.00-1.14), and 415 of 555 women in the oil group (74.8%) and 376 of 559 women in the water group (67.3%) had live births (RR 1.11; 95% CI 1.03-1.20). In the oil group, 228 pregnancies (41.1%) were conceived naturally versus 194 (34.7%) pregnancies in the water group (RR 1.18; 95% CI 1.02-1.38). The time to ongoing pregnancy was significantly shorter in the oil group versus the water group (10.0 vs. 13.7 months; hazard ratio, 1.25; 95% CI 1.09-1.43). No difference was found in the occurrence of a second ongoing pregnancy.CONCLUSION(S): During a 5-year time frame, ongoing pregnancy and live birth rates are higher after tubal flushing with oil-based contrast during HSG compared with water-based contrast. More pregnancies are naturally conceived and time to ongoing pregnancy is shorter after HSG with oil-based contrast.CLINICAL TRIAL REGISTRATION NUMBER: Netherlands Trial Register (NTR) 3270 and NTR6577(www.trialregister.nl).
KW - Female infertility
KW - hysterosalpingography
KW - oil-based contrast medium
KW - ongoing pregnancy
KW - water-based contrast medium
UR - http://www.scopus.com/inward/record.url?scp=85086119257&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.fertnstert.2020.03.022
DO - https://doi.org/10.1016/j.fertnstert.2020.03.022
M3 - Article
C2 - 32553471
SN - 0015-0282
VL - 114
SP - 155
EP - 162
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -