TY - JOUR
T1 - Tumor grafted - chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation
AU - Mapanao, Ana Katrina
AU - Che, Pei Pei
AU - Sarogni, Patrizia
AU - Sminia, Peter
AU - Giovannetti, Elisa
AU - Voliani, Valerio
N1 - Funding Information: This work was supported by Associazione Italiana per la Ricerca sul Cancro (AIRC) under MFAG 2017?ID 19852 project?P.I. Voliani Valerio, AIRC Start-Up #14422 project?P.I. Elisa Giovannetti, and Zabawas Foundation/Cancer Center Amsterdam (CCA) project #2006784?P.I. Peter Sminia. The authors would like to thank Ms. Kitty Castricum for images on Suit2.28wt, Dr. Claudia Kusmic, and Ms. Sabrina Marchetti for the UPCI:SCC-154 H&E image. Figures 1(c), 2(a), 2c, and 5 were created with BioRender.com. Permissions were obtained for the following reproduced figures: Figure 1(a) = Adapted from Romanoff (Cornell Rural School Leaflet) [12] and Smith [13]. Copyright 2019 by the Mississippi State University Extension Service; Figure 2(d) = Reproduced with permission from Deryugina and Kiosses [81]. Copyright 2017 by the authors; Figure 4(a) = Reproduced from Warnock et al. [98]. Copyright 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc.; Figure 3(b) = Reproduced from Winter et al. [99]. Copyright 2020 by the authors; Figure 4(c) = Reproduced with permission from Vargas et al. [171]. Copyright 2007 by Elsevier B.V.; Figure 4(d) = Reproduced with permission from Steinmetz et al. [137]. Copyright 2011 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim; Figure 4(e) = Adapted from Rovithi et al. [11]. Copyright 2017 by the authors; Figure 4F = Reproduced from Kutwin et al. [149]. Copyright 2016 by Termedia & Banach. Publisher Copyright: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Introduction: Advancements in cancer management and treatment are associated with strong preclinical research data, in which reliable cancer models are demanded. Indeed, inconsistent preclinical findings and stringent regulations following the 3Rs principle of reduction, refinement, and replacement of conventional animal models currently pose challenges in the development and translation of efficient technologies. The chick embryo chorioallantoic membrane (CAM) is a system for the evaluation of treatment effects on the vasculature, therefore suitable for studies on angiogenesis. Apart from vascular effects, the model is now increasingly employed as a preclinical cancer model following tumor-grafting procedures. Areas covered: The broad application of CAM tumor model is highlighted along with the methods for analyzing the neoplasm and vascular system. The presented and cited investigations focus on cancer biology and treatment, encompassing both conventional and emerging nanomaterial-based modalities. Expert opinion: The CAM tumor model finds increased significance given the influences of angiogenesis and the tumor microenvironment in cancer behavior, then providing a qualified miniature system for oncological research. Ultimately, the establishment and increased employment of such a model may resolve some of the limitations present in the standard preclinical tumor models, thereby redefining the preclinical research workflow.
AB - Introduction: Advancements in cancer management and treatment are associated with strong preclinical research data, in which reliable cancer models are demanded. Indeed, inconsistent preclinical findings and stringent regulations following the 3Rs principle of reduction, refinement, and replacement of conventional animal models currently pose challenges in the development and translation of efficient technologies. The chick embryo chorioallantoic membrane (CAM) is a system for the evaluation of treatment effects on the vasculature, therefore suitable for studies on angiogenesis. Apart from vascular effects, the model is now increasingly employed as a preclinical cancer model following tumor-grafting procedures. Areas covered: The broad application of CAM tumor model is highlighted along with the methods for analyzing the neoplasm and vascular system. The presented and cited investigations focus on cancer biology and treatment, encompassing both conventional and emerging nanomaterial-based modalities. Expert opinion: The CAM tumor model finds increased significance given the influences of angiogenesis and the tumor microenvironment in cancer behavior, then providing a qualified miniature system for oncological research. Ultimately, the establishment and increased employment of such a model may resolve some of the limitations present in the standard preclinical tumor models, thereby redefining the preclinical research workflow.
KW - Angiogenesis
KW - chemotherapy
KW - chorioallantoic membrane
KW - nanomedicine
KW - radiotherapy
KW - tumor models
UR - http://www.scopus.com/inward/record.url?scp=85100971320&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/17425255.2021.1879047
DO - https://doi.org/10.1080/17425255.2021.1879047
M3 - Review article
C2 - 33565346
SN - 1742-5255
VL - 17
SP - 947
EP - 968
JO - Expert Opinion on Drug Metabolism and Toxicology
JF - Expert Opinion on Drug Metabolism and Toxicology
IS - 8
ER -