Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients

Esther P. M. Tjin; Rosalie M. Luiten

doi:https://doi.org/10.4161/21624011.2014.954862

Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients

Esther P. M. Tjin, Rosalie M. Luiten

Research output: Contribution to journal › Editorial › Academic › peer-review

4 Citations (Scopus)

Abstract

Immune escape mechanisms are prevalent in tumors, while their influence on the potency of antitumor immunotherapy has yet to be distinguished. We recently showed that increased numbers of intratumoral T cells rather than immune-escape-mechanisms significantly correlated with clinical outcome of advanced melanoma patients to subsequent autologous tumor cell vaccination. Our data emphasize the therapeutic relevance of tumor-infiltrating T cells for the clinical outcome

Original language	English
Pages (from-to)	e954862
Journal	Oncoimmunology
Volume	3
Issue number	9
DOIs	https://doi.org/10.4161/21624011.2014.954862
Publication status	Published - 2014

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https://doi.org/10.4161/21624011.2014.954862

Cite this

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title = "Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients",

abstract = "Immune escape mechanisms are prevalent in tumors, while their influence on the potency of antitumor immunotherapy has yet to be distinguished. We recently showed that increased numbers of intratumoral T cells rather than immune-escape-mechanisms significantly correlated with clinical outcome of advanced melanoma patients to subsequent autologous tumor cell vaccination. Our data emphasize the therapeutic relevance of tumor-infiltrating T cells for the clinical outcome",

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AU - Tjin, Esther P. M.

AU - Luiten, Rosalie M.

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AB - Immune escape mechanisms are prevalent in tumors, while their influence on the potency of antitumor immunotherapy has yet to be distinguished. We recently showed that increased numbers of intratumoral T cells rather than immune-escape-mechanisms significantly correlated with clinical outcome of advanced melanoma patients to subsequent autologous tumor cell vaccination. Our data emphasize the therapeutic relevance of tumor-infiltrating T cells for the clinical outcome

U2 - https://doi.org/10.4161/21624011.2014.954862

DO - https://doi.org/10.4161/21624011.2014.954862

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