Tumor necrosis factor is involved in the appearance of interleukin-1 receptor antagonist in endotoxemia

T. van der Poll; S. J. van Deventer; H. ten Cate; M. [=Marcel M.] Levi; J. W. ten Cate

doi:https://doi.org/10.1093/infdis/169.3.665

Tumor necrosis factor is involved in the appearance of interleukin-1 receptor antagonist in endotoxemia

T. van der Poll, S. J. van Deventer, H. ten Cate, M. [=Marcel M.] Levi, J. W. ten Cate

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

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Abstract

To assess the role of tumor necrosis factor (TNF) in the appearance of interleukin-1 receptor antagonist (IL-1RA) in endotoxemia, 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF (50 micrograms/m2). In addition, 8 healthy chimpanzees were investigated after a bolus intravenous injection of Escherichia coli endotoxin (4 ng/kg) with (n = 4) or without (n = 4) a simultaneous intravenous injection of a monoclonal anti-TNF antibody (15 mg/kg). TNF induced a pronounced rise in IL-1RA concentrations, becoming apparent after 1 h and peaking after 3 h (P <.05). The rise in IL-1RA after administration of endotoxin started 2 h later. Neutralization of the early endotoxin-induced TNF activity by anti-TNF caused a marked reduction in IL-1RA concentrations (P <.05). These results indicate that TNF is an intermediate factor in IL-1RA release in endotoxemia

Original language	English
Pages (from-to)	665-667
Journal	Journal of infectious diseases
Volume	169
Issue number	3
DOIs	https://doi.org/10.1093/infdis/169.3.665
Publication status	Published - 1994

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https://doi.org/10.1093/infdis/169.3.665

Cite this

@article{ef2b05070b58438f835d32626724b769,

title = "Tumor necrosis factor is involved in the appearance of interleukin-1 receptor antagonist in endotoxemia",

abstract = "To assess the role of tumor necrosis factor (TNF) in the appearance of interleukin-1 receptor antagonist (IL-1RA) in endotoxemia, 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF (50 micrograms/m2). In addition, 8 healthy chimpanzees were investigated after a bolus intravenous injection of Escherichia coli endotoxin (4 ng/kg) with (n = 4) or without (n = 4) a simultaneous intravenous injection of a monoclonal anti-TNF antibody (15 mg/kg). TNF induced a pronounced rise in IL-1RA concentrations, becoming apparent after 1 h and peaking after 3 h (P <.05). The rise in IL-1RA after administration of endotoxin started 2 h later. Neutralization of the early endotoxin-induced TNF activity by anti-TNF caused a marked reduction in IL-1RA concentrations (P <.05). These results indicate that TNF is an intermediate factor in IL-1RA release in endotoxemia",

author = "{van der Poll}, T. and {van Deventer}, {S. J.} and {ten Cate}, H. and Levi, {M. [=Marcel M.]} and {ten Cate}, {J. W.}",

year = "1994",

doi = "https://doi.org/10.1093/infdis/169.3.665",

language = "English",

volume = "169",

pages = "665--667",

journal = "Journal of infectious diseases",

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TY - JOUR

T1 - Tumor necrosis factor is involved in the appearance of interleukin-1 receptor antagonist in endotoxemia

AU - van der Poll, T.

AU - van Deventer, S. J.

AU - ten Cate, H.

AU - Levi, M. [=Marcel M.]

AU - ten Cate, J. W.

PY - 1994

Y1 - 1994

N2 - To assess the role of tumor necrosis factor (TNF) in the appearance of interleukin-1 receptor antagonist (IL-1RA) in endotoxemia, 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF (50 micrograms/m2). In addition, 8 healthy chimpanzees were investigated after a bolus intravenous injection of Escherichia coli endotoxin (4 ng/kg) with (n = 4) or without (n = 4) a simultaneous intravenous injection of a monoclonal anti-TNF antibody (15 mg/kg). TNF induced a pronounced rise in IL-1RA concentrations, becoming apparent after 1 h and peaking after 3 h (P <.05). The rise in IL-1RA after administration of endotoxin started 2 h later. Neutralization of the early endotoxin-induced TNF activity by anti-TNF caused a marked reduction in IL-1RA concentrations (P <.05). These results indicate that TNF is an intermediate factor in IL-1RA release in endotoxemia

AB - To assess the role of tumor necrosis factor (TNF) in the appearance of interleukin-1 receptor antagonist (IL-1RA) in endotoxemia, 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF (50 micrograms/m2). In addition, 8 healthy chimpanzees were investigated after a bolus intravenous injection of Escherichia coli endotoxin (4 ng/kg) with (n = 4) or without (n = 4) a simultaneous intravenous injection of a monoclonal anti-TNF antibody (15 mg/kg). TNF induced a pronounced rise in IL-1RA concentrations, becoming apparent after 1 h and peaking after 3 h (P <.05). The rise in IL-1RA after administration of endotoxin started 2 h later. Neutralization of the early endotoxin-induced TNF activity by anti-TNF caused a marked reduction in IL-1RA concentrations (P <.05). These results indicate that TNF is an intermediate factor in IL-1RA release in endotoxemia

U2 - https://doi.org/10.1093/infdis/169.3.665

DO - https://doi.org/10.1093/infdis/169.3.665

M3 - Comment/Letter to the editor

C2 - 8158047

SN - 0022-1899

VL - 169

SP - 665

EP - 667

JO - Journal of infectious diseases

JF - Journal of infectious diseases

IS - 3

ER -