Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium

Frank J. Wolters; Lori B. Chibnik; Reem Waziry; Roy Anderson; Claudine Berr; Alexa Beiser; Joshua C. Bis; Deborah Blacker; Daniel Bos; Carol Brayne; Jean-François Dartigues; Sirwan K. L. Darweesh; Kendra L. Davis-Plourde; Frank de Wolf; Stephanie Debette; Carole Dufouil; Myriam Fornage; Jaap Goudsmit; Leslie Grasset; Vilmundur Gudnason; Christoforos Hadjichrysanthou; Catherine Helmer; M. Arfan Ikram; M. Kamran Ikram; Erik Joas; Silke Kern; Lewis H. Kuller; Lenore Launer; Oscar L. Lopez; Fiona E. Matthews; Kevin McRae-McKee; Osorio Meirelles; Thomas H. Mosley; Matthew P. Pase; Bruce M. Psaty; Claudia L. Satizabal; Sudha Seshadri; Ingmar Skoog; Blossom C. M. Stephan; Hanna Wetterberg; Mei Mei Wong; Anna Zettergren; Albert Hofman

doi:https://doi.org/10.1212/WNL.0000000000010022

Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium

Frank J. Wolters, Lori B. Chibnik, Reem Waziry, Roy Anderson, Claudine Berr, Alexa Beiser, Joshua C. Bis, Deborah Blacker, Daniel Bos, Carol Brayne, Jean-François Dartigues, Sirwan K. L. Darweesh, Kendra L. Davis-Plourde, Frank de Wolf, Stephanie Debette, Carole Dufouil, Myriam Fornage, Jaap Goudsmit, Leslie Grasset, Vilmundur GudnasonChristoforos Hadjichrysanthou, Catherine Helmer, M. Arfan Ikram, M. Kamran Ikram, Erik Joas, Silke Kern, Lewis H. Kuller, Lenore Launer, Oscar L. Lopez, Fiona E. Matthews, Kevin McRae-McKee, Osorio Meirelles, Thomas H. Mosley, Matthew P. Pase, Bruce M. Psaty, Claudia L. Satizabal, Sudha Seshadri, Ingmar Skoog, Blossom C. M. Stephan, Hanna Wetterberg, Mei Mei Wong, Anna Zettergren, Albert Hofman

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.

Original language	English
Pages (from-to)	e519-e531
Journal	Neurology
Volume	95
Issue number	5
DOIs	https://doi.org/10.1212/WNL.0000000000010022
Publication status	Published - 4 Aug 2020
Externally published	Yes

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Wolters, F. J., Chibnik, L. B., Waziry, R., Anderson, R., Berr, C., Beiser, A., Bis, J. C., Blacker, D., Bos, D., Brayne, C., Dartigues, J.-F., Darweesh, S. K. L., Davis-Plourde, K. L., de Wolf, F., Debette, S., Dufouil, C., Fornage, M., Goudsmit, J., Grasset, L., ... Hofman, A. (2020). Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium. Neurology, 95(5), e519-e531. https://doi.org/10.1212/WNL.0000000000010022

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title = "Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium",

abstract = "OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.",

author = "Wolters, {Frank J.} and Chibnik, {Lori B.} and Reem Waziry and Roy Anderson and Claudine Berr and Alexa Beiser and Bis, {Joshua C.} and Deborah Blacker and Daniel Bos and Carol Brayne and Jean-Fran{\c c}ois Dartigues and Darweesh, {Sirwan K. L.} and Davis-Plourde, {Kendra L.} and {de Wolf}, Frank and Stephanie Debette and Carole Dufouil and Myriam Fornage and Jaap Goudsmit and Leslie Grasset and Vilmundur Gudnason and Christoforos Hadjichrysanthou and Catherine Helmer and Ikram, {M. Arfan} and Ikram, {M. Kamran} and Erik Joas and Silke Kern and Kuller, {Lewis H.} and Lenore Launer and Lopez, {Oscar L.} and Matthews, {Fiona E.} and Kevin McRae-McKee and Osorio Meirelles and Mosley, {Thomas H.} and Pase, {Matthew P.} and Psaty, {Bruce M.} and Satizabal, {Claudia L.} and Sudha Seshadri and Ingmar Skoog and Stephan, {Blossom C. M.} and Hanna Wetterberg and Wong, {Mei Mei} and Anna Zettergren and Albert Hofman",

year = "2020",

month = aug,

day = "4",

doi = "https://doi.org/10.1212/WNL.0000000000010022",

language = "English",

volume = "95",

pages = "e519--e531",

journal = "Neurology",

issn = "0028-3878",

publisher = "American Academy of Neurology",

number = "5",

}

Wolters, FJ, Chibnik, LB, Waziry, R, Anderson, R, Berr, C, Beiser, A, Bis, JC, Blacker, D, Bos, D, Brayne, C, Dartigues, J-F, Darweesh, SKL, Davis-Plourde, KL, de Wolf, F, Debette, S, Dufouil, C, Fornage, M, Goudsmit, J, Grasset, L, Gudnason, V, Hadjichrysanthou, C, Helmer, C, Ikram, MA, Ikram, MK, Joas, E, Kern, S, Kuller, LH, Launer, L, Lopez, OL, Matthews, FE, McRae-McKee, K, Meirelles, O, Mosley, TH, Pase, MP, Psaty, BM, Satizabal, CL, Seshadri, S, Skoog, I, Stephan, BCM, Wetterberg, H, Wong, MM, Zettergren, A & Hofman, A 2020, 'Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium', Neurology, vol. 95, no. 5, pp. e519-e531. https://doi.org/10.1212/WNL.0000000000010022

TY - JOUR

T1 - Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium

AU - Wolters, Frank J.

AU - Chibnik, Lori B.

AU - Waziry, Reem

AU - Anderson, Roy

AU - Berr, Claudine

AU - Beiser, Alexa

AU - Bis, Joshua C.

AU - Blacker, Deborah

AU - Bos, Daniel

AU - Brayne, Carol

AU - Dartigues, Jean-François

AU - Darweesh, Sirwan K. L.

AU - Davis-Plourde, Kendra L.

AU - de Wolf, Frank

AU - Debette, Stephanie

AU - Dufouil, Carole

AU - Fornage, Myriam

AU - Goudsmit, Jaap

AU - Grasset, Leslie

AU - Gudnason, Vilmundur

AU - Hadjichrysanthou, Christoforos

AU - Helmer, Catherine

AU - Ikram, M. Arfan

AU - Ikram, M. Kamran

AU - Joas, Erik

AU - Kern, Silke

AU - Kuller, Lewis H.

AU - Launer, Lenore

AU - Lopez, Oscar L.

AU - Matthews, Fiona E.

AU - McRae-McKee, Kevin

AU - Meirelles, Osorio

AU - Mosley, Thomas H.

AU - Pase, Matthew P.

AU - Psaty, Bruce M.

AU - Satizabal, Claudia L.

AU - Seshadri, Sudha

AU - Skoog, Ingmar

AU - Stephan, Blossom C. M.

AU - Wetterberg, Hanna

AU - Wong, Mei Mei

AU - Zettergren, Anna

AU - Hofman, Albert

PY - 2020/8/4

Y1 - 2020/8/4

N2 - OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.

AB - OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.

UR - http://www.scopus.com/inward/record.url?scp=85089127421&partnerID=8YFLogxK

U2 - https://doi.org/10.1212/WNL.0000000000010022

DO - https://doi.org/10.1212/WNL.0000000000010022

M3 - Article

C2 - 32611641

SN - 0028-3878

VL - 95

SP - e519-e531

JO - Neurology

JF - Neurology

IS - 5

ER -

Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium

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