TY - JOUR
T1 - Type 2 diabetes is associated with postprandial amino acid measures
AU - Mook-Kanamori, Dennis O.
AU - De Mutsert, Renée
AU - Rensen, Patrick C.N.
AU - Prehn, Cornelia
AU - Adamski, Jerzy
AU - Den Heijer, Martin
AU - Le Cessie, Saskia
AU - Suhre, Karsten
AU - Rosendaal, Frits R.
AU - Dijk, Ko Willems Van
N1 - Funding Information: The NEO study is supported by the participating Departments, the Division and the Board of Directors of the Leiden University Medical Center, and by the Leiden University, Research Profile Area Vascular and Regenerative Medicine. In this study the metabolomics measurements and the work of Dennis Mook-Kanamori were supported by Dutch Science Organization (ZonMW-VENI Grant 916.14.023 ). Patrick C.N. Rensen is Established Investigator of the Dutch Heart Foundation ( 2009T038 ). This study was supported in part by a grant from the German Federal Ministry of Education and Research (BMBF) to the German Center Diabetes Research (DZD e.V.). Karsten Suhre was supported by ‘Biomedical Research Program’ funds at Weill Cornell Medical College in Qatar, a program funded by the Qatar Foundation . Publisher Copyright: © 2015 Elsevier Inc. All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Most studies examining the association between type 2 diabetes (T2D) and amino acids have focused on fasting concentrations. We hypothesized that, besides fasting concentrations, amino acid responses to a standardized meal challenge are also associated with T2D. In a cross-sectional study of 525 participants (165 newly-diagnosed T2D, 186 newly-diagnosed impaired fasting glycaemia, and 174 normal fasting glucose), we examined postprandial amino acid concentrations and the responses (defined as the concentrations and responses 150 min after a standardized meal) of fourteen amino acids in relation to T2D. T2D was associated with lower postprandial concentration of seven amino acids compared to the normal fasting glucose group (lowest effect estimate for serine: -0.54 standard deviations (SD) (95% CI: -0.77, -0.32)), and higher concentrations of phenylalanine, tryptophan, tyrosine and (iso-)leucine (highest effect estimate for (iso-)leucine: 0.44 SD (95% CI: 0.20, 0.67)). Regarding the meal responses, T2D was associated with lower responses of seven amino acids (ranging from -0.55 SD ((95% CI): -0.78, -0.33) for serine to -0.25 SD ((95% CI: -0.45, -0.02) for ornithine). We conclude that T2D is associated with postprandial concentrations of amino acids and a reduced amino acid meal response, indicating that these measures may also be potential markers of T2D.
AB - Most studies examining the association between type 2 diabetes (T2D) and amino acids have focused on fasting concentrations. We hypothesized that, besides fasting concentrations, amino acid responses to a standardized meal challenge are also associated with T2D. In a cross-sectional study of 525 participants (165 newly-diagnosed T2D, 186 newly-diagnosed impaired fasting glycaemia, and 174 normal fasting glucose), we examined postprandial amino acid concentrations and the responses (defined as the concentrations and responses 150 min after a standardized meal) of fourteen amino acids in relation to T2D. T2D was associated with lower postprandial concentration of seven amino acids compared to the normal fasting glucose group (lowest effect estimate for serine: -0.54 standard deviations (SD) (95% CI: -0.77, -0.32)), and higher concentrations of phenylalanine, tryptophan, tyrosine and (iso-)leucine (highest effect estimate for (iso-)leucine: 0.44 SD (95% CI: 0.20, 0.67)). Regarding the meal responses, T2D was associated with lower responses of seven amino acids (ranging from -0.55 SD ((95% CI): -0.78, -0.33) for serine to -0.25 SD ((95% CI: -0.45, -0.02) for ornithine). We conclude that T2D is associated with postprandial concentrations of amino acids and a reduced amino acid meal response, indicating that these measures may also be potential markers of T2D.
KW - Amino acids
KW - Epidemiology
KW - Meal response
KW - Metabolomics
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84950327230&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.abb.2015.08.003
DO - https://doi.org/10.1016/j.abb.2015.08.003
M3 - Review article
C2 - 26271442
SN - 0003-9861
VL - 589
SP - 138
EP - 144
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
ER -