TY - JOUR
T1 - Type-specific concurrent anogenital HPV detection among young women and MSM attending Dutch sexual health clinics
AU - Kusters, Johannes M. A.
AU - Heijne, Janneke C. M.
AU - van Benthem, Birgit H. B.
AU - King, Audrey J.
AU - Schim van der Loeff, Maarten F.
N1 - Funding Information: This work was supported by the Ministry of Health, Welfare and Sport, the Netherlands. Publisher Copyright: © 2023 BMJ Publishing Group. All rights reserved.
PY - 2023/6/1
Y1 - 2023/6/1
N2 - Objectives This study aimed to investigate type-specific concurrent anogenital human papillomavirus (HPV) detection and examine associations with concurrent detection. Methods Data from a Dutch repeated cross-sectional study among young sexual health clinic visitors (Papillomavirus Surveillance among STI clinic Youngsters in the Netherlands) between 2009 and 2019 were used. Cohen's kappa was used to assess the degree of type-specific concordance of HPV detection between anal and genital sites for 25 HPV genotypes for women and men who have sex with men (MSM) separately. Associations with type-specific concurrent HPV were identified. Receptive anal intercourse (RAI) was forced into the model to investigate its influence. Results Among women (n=1492), type-specific concurrent anogenital detection was common; kappa was above 0.4 for 20 genotypes. Among MSM (n=614), kappa was <0.4 for all genotypes. The only significant association with type-specific concurrent anogenital detection among women was genital chlamydia (adjusted OR 1.5, 95% CI 1.1 to 2.2). RAI was not associated. Conclusions Type-specific concurrent anogenital HPV detection was common among young women, and uncommon among MSM. For women, concurrent HPV detection was associated with genital chlamydia. Our results are suggestive of autoinoculation of HPV among women.
AB - Objectives This study aimed to investigate type-specific concurrent anogenital human papillomavirus (HPV) detection and examine associations with concurrent detection. Methods Data from a Dutch repeated cross-sectional study among young sexual health clinic visitors (Papillomavirus Surveillance among STI clinic Youngsters in the Netherlands) between 2009 and 2019 were used. Cohen's kappa was used to assess the degree of type-specific concordance of HPV detection between anal and genital sites for 25 HPV genotypes for women and men who have sex with men (MSM) separately. Associations with type-specific concurrent HPV were identified. Receptive anal intercourse (RAI) was forced into the model to investigate its influence. Results Among women (n=1492), type-specific concurrent anogenital detection was common; kappa was above 0.4 for 20 genotypes. Among MSM (n=614), kappa was <0.4 for all genotypes. The only significant association with type-specific concurrent anogenital detection among women was genital chlamydia (adjusted OR 1.5, 95% CI 1.1 to 2.2). RAI was not associated. Conclusions Type-specific concurrent anogenital HPV detection was common among young women, and uncommon among MSM. For women, concurrent HPV detection was associated with genital chlamydia. Our results are suggestive of autoinoculation of HPV among women.
KW - epidemiology
KW - papillomaviridae
KW - rectal diseases
KW - sexual health
UR - http://www.scopus.com/inward/record.url?scp=85145907040&partnerID=8YFLogxK
U2 - https://doi.org/10.1136/sextrans-2022-055484
DO - https://doi.org/10.1136/sextrans-2022-055484
M3 - Article
C2 - 35842228
SN - 1368-4973
VL - 99
SP - 239
EP - 247
JO - Sexually transmitted infections
JF - Sexually transmitted infections
IS - 4
ER -