Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis

J.M. Wagner, T.J. Evans, J. Chen, H.N. Zhu, E.N.G. Houben, W. Bitter, K.V. Korotkov

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)


Mycobacteria use specialized ESX secretion systems to transport proteins across their cell membranes in order to manipulate their environment. In pathogenic Mycobacterium tuberculosis there are five paralogous ESX secretion systems, named ESX-1 through ESX-5. Each system includes a subtilisin-like protease (mycosin or MycP) as a core component essential for secretion. Here we report crystal structures of MycP
Original languageEnglish
Pages (from-to)115-128
JournalJournal of structural biology
Issue number2
Publication statusPublished - 2013

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