Undifferentiated connective tissue disease: State of the art on clinical practice guidelines

Margarida Antunes, Carlo Alberto Scirè, Rosaria Talarico, Tobias Alexander, Tadej Avcin, Chiara Belocchi, Andrea Doria, Franco Franceschini, Ilaria Galetti, Marcello Govoni, Eric Hachulla, David Launay, Gemma Lepri, Carla Macieira, Marco Matucci-Cerinic, Carlo Maurizio Montecucco, Maria Francisca Moraes-Fontes, Luc Mouthon, Sabrina Paolino, Veronique RamoniChiara Tani, Sander W. Tas, Angela Tincani, Ronald van Vollenhoven, Margherita Zen, Joao Fonseca, Stefano Bombardieri, João Eurico Fonseca, Matthias Schneider, Vanessa Smith, Maurizio Cutolo, Marta Mosca, Lorenzo Beretta

Research output: Contribution to journalReview articleAcademicpeer-review

34 Citations (Scopus)


The term a € undifferentiated connective tissue disease' (UCTD) is generally used to describe clinical entities characterised by clinical and serological manifestations of systemic autoimmune diseases but not fulfilling the criteria for defined connective tissue diseases (CTDs). In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the ERN ReCONNET project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations. No specific CPG on UCTD were found, potential areas of intervention are absence of a consensus definition of UCTD, need for specific monitoring and therapeutic protocols, stratification of UCTD based on the risk of developing a defined CTD and preventive measure for the future development of a more severe condition. Patients feel uncertainty regarding the name of the disease and feel the need of a better education and understanding of these conditions and its possible changes over time.
Original languageEnglish
Article numbere000786
Pages (from-to)e000786
Issue numberSuppl 1
Publication statusPublished - 1 Feb 2019

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