TY - JOUR
T1 - Unexpected Detection of Nodular Melanoma of the Skin on the Scalp by I-123 IBZM Brain SPECT
AU - Booij, Jan
AU - Boot, Erik
AU - van Eeden, Susanne
AU - van Amelsvoort, Thérèse
PY - 2011
Y1 - 2011
N2 - Melanocytes and dopaminergic neurons share the same ectodermal origin and can both produce melanin. Indeed, in vivo studies have shown that the radiopharmaceutical iodine-123-iodobenzamide (I-123 IBZM), which binds in vivo to dopamine D-2/3 receptors, is also able to detect melanoma, and particularly melanotic melanoma. We report a case of intense IBZM uptake in nodular melanoma of the skin on the scalp. The presence of unexpected focal IBZM uptake of the skin justified histologic examination, which revealed nodular melanoma. Melanoma should be considered when one is confronted with atypical focal uptake of benzamide derivatives like IBZM, in or outside the brain
AB - Melanocytes and dopaminergic neurons share the same ectodermal origin and can both produce melanin. Indeed, in vivo studies have shown that the radiopharmaceutical iodine-123-iodobenzamide (I-123 IBZM), which binds in vivo to dopamine D-2/3 receptors, is also able to detect melanoma, and particularly melanotic melanoma. We report a case of intense IBZM uptake in nodular melanoma of the skin on the scalp. The presence of unexpected focal IBZM uptake of the skin justified histologic examination, which revealed nodular melanoma. Melanoma should be considered when one is confronted with atypical focal uptake of benzamide derivatives like IBZM, in or outside the brain
U2 - https://doi.org/10.1097/RLU.0b013e318203be54
DO - https://doi.org/10.1097/RLU.0b013e318203be54
M3 - Editorial
C2 - 21220985
SN - 0363-9762
VL - 36
SP - 148
EP - 149
JO - Clinical nuclear medicine
JF - Clinical nuclear medicine
IS - 2
ER -