Unintentional ingestion of a high dose of acenocoumarol in a young child

Martijn R. Brands; Jelmer Sytema; Marinus van Hulst; Arvid W. A. Kamps

doi:https://doi.org/10.1136/bcr-2020-240365

Unintentional ingestion of a high dose of acenocoumarol in a young child

Martijn R. Brands, Jelmer Sytema, Marinus van Hulst, Arvid W. A. Kamps

Doctoral School

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Acute intoxication with a Vitamin K antagonist may cause serious coagulopathy. We report the accidental ingestion of a high dose of acenocoumarol in a young child. Two intravenous administrations of 5 mg of Vitamin K, in combination with fast and repeated administration of activated charcoal and sodium sulfate, were sufficient to prevent coagulopathy and related symptoms, despite a confirmed elevated blood acenocoumarol concentration (260 μg/L).

Original language	English
Article number	e240365
Journal	BMJ Case Reports
Volume	14
Issue number	4
DOIs	https://doi.org/10.1136/bcr-2020-240365
Publication status	Published - 1 Apr 2021

Keywords

haematology (drugs and medicines)
haematology (incl blood transfusion)
paediatrics (drugs and medicines)
poisoning
warfarin therapy

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title = "Unintentional ingestion of a high dose of acenocoumarol in a young child",

abstract = "Acute intoxication with a Vitamin K antagonist may cause serious coagulopathy. We report the accidental ingestion of a high dose of acenocoumarol in a young child. Two intravenous administrations of 5 mg of Vitamin K, in combination with fast and repeated administration of activated charcoal and sodium sulfate, were sufficient to prevent coagulopathy and related symptoms, despite a confirmed elevated blood acenocoumarol concentration (260 μg/L).",

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AU - Kamps, Arvid W. A.

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AB - Acute intoxication with a Vitamin K antagonist may cause serious coagulopathy. We report the accidental ingestion of a high dose of acenocoumarol in a young child. Two intravenous administrations of 5 mg of Vitamin K, in combination with fast and repeated administration of activated charcoal and sodium sulfate, were sufficient to prevent coagulopathy and related symptoms, despite a confirmed elevated blood acenocoumarol concentration (260 μg/L).

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Unintentional ingestion of a high dose of acenocoumarol in a young child

Abstract

Keywords

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