Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

ENETS 2016 Munich Advisory Board Participants; Jaroslaw B. Cwikła

doi:https://doi.org/10.1159/000493980

Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

ENETS 2016 Munich Advisory Board Participants, Jaroslaw B. Cwikła

Research output: Contribution to journal › Review article › Academic › peer-review

16 Citations (Scopus)

Abstract

Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

Original language	English
Pages (from-to)	7-17
Number of pages	11
Journal	Neuroendocrinology
Volume	108
Issue number	1
DOIs	https://doi.org/10.1159/000493980
Publication status	Published - 1 Jan 2019

Keywords

Biomedical Research/trends
Carcinoid Tumor/classification
Humans
Lung Neoplasms/classification
Neuroendocrine Tumors/classification
Prognosis

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https://doi.org/10.1159/000493980

http://hdl.handle.net/10044/1/64851

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title = "Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms",

abstract = "Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.",

keywords = "Biomedical Research/trends, Carcinoid Tumor/classification, Humans, Lung Neoplasms/classification, Neuroendocrine Tumors/classification, Prognosis",

author = "ENETS 2016 Munich Advisory Board Participants and Eric Baudin and Hayes, {Aimee R} and Jean-Yves Scoazec and Filosso, {Pier Luigi} and Eric Lim and Gregory Kaltsas and Andrea Frilling and Jie Chen and Beata Kos-Kud{\l}a and Vera Gorbunova and Bertram Wiedenmann and {Nieveen van Dijkum}, Els and {\'C}wik{\l}a, {Jaroslaw B} and Jenny Falkerby and Valle, {Juan W} and Kulke, {Matthew H} and Caplin, {Martyn E} and Cwik{\l}a, {Jaroslaw B.}",

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AU - ENETS 2016 Munich Advisory Board Participants

AU - Baudin, Eric

AU - Hayes, Aimee R

AU - Scoazec, Jean-Yves

AU - Filosso, Pier Luigi

AU - Lim, Eric

AU - Kaltsas, Gregory

AU - Frilling, Andrea

AU - Chen, Jie

AU - Kos-Kudła, Beata

AU - Gorbunova, Vera

AU - Wiedenmann, Bertram

AU - Nieveen van Dijkum, Els

AU - Ćwikła, Jaroslaw B

AU - Falkerby, Jenny

AU - Valle, Juan W

AU - Kulke, Matthew H

AU - Caplin, Martyn E

AU - Cwikła, Jaroslaw B.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

AB - Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

KW - Biomedical Research/trends

KW - Carcinoid Tumor/classification

KW - Humans

KW - Lung Neoplasms/classification

KW - Neuroendocrine Tumors/classification

KW - Prognosis

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Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

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Keywords

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