TY - JOUR
T1 - Unmet Needs in Appendiceal Neuroendocrine Neoplasms
AU - The ENETS 2016 Munich Advisory Board Participants
AU - Toumpanakis, Christos
AU - Fazio, Nicola
AU - Tiensuu Janson, Eva
AU - Hörsch, Dieter
AU - Pascher, Andreas
AU - Reed, Nicholas
AU - O Apos Toole, Dermot
AU - Nieveen van Dijkum, Els
AU - Partelli, Stefano
AU - Rinke, Anja
AU - Kos-Kudla, Beata
AU - Costa, Frederico
AU - Pape, Ulrich-Frank
AU - Grozinsky-Glasberg, Simona
AU - Scoazec, Jean-Yves
AU - O'Apostoole, Dermot
N1 - © 2018 S. Karger AG, Basel.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Appendiceal neuroendocrine neoplasms (ANEN) are mostly discovered coincidentally during appendicectomy and usually have a benign clinical course; thus, appendicectomy alone is considered curative. However, in some cases, a malignant potential is suspected, and therefore additional operations such as completion right hemicolectomy are considered. The existing European Neuroendocrine Tumour Society (ENETS) guidelines provide useful data about epidemiology and prognosis, as well as practical recommendations with regards to the risk factors for a more aggressive disease course and the indications for a secondary operation. However, these guidelines are based on heterogeneous and retrospective studies. Therefore, the evidence does not seem to be robust, and there are still unmet needs in terms of accurate epidemiology and overall prognosis, optimal diagnostic and follow-up strategy, as well as identified risk factors that would indicate a more aggressive surgical approach at the beginning and a more intense follow-up. In this review, we are adopting a critical approach of the ENETS guidelines and published series for ANEN, focusing on the above-noted "grey areas".
AB - Appendiceal neuroendocrine neoplasms (ANEN) are mostly discovered coincidentally during appendicectomy and usually have a benign clinical course; thus, appendicectomy alone is considered curative. However, in some cases, a malignant potential is suspected, and therefore additional operations such as completion right hemicolectomy are considered. The existing European Neuroendocrine Tumour Society (ENETS) guidelines provide useful data about epidemiology and prognosis, as well as practical recommendations with regards to the risk factors for a more aggressive disease course and the indications for a secondary operation. However, these guidelines are based on heterogeneous and retrospective studies. Therefore, the evidence does not seem to be robust, and there are still unmet needs in terms of accurate epidemiology and overall prognosis, optimal diagnostic and follow-up strategy, as well as identified risk factors that would indicate a more aggressive surgical approach at the beginning and a more intense follow-up. In this review, we are adopting a critical approach of the ENETS guidelines and published series for ANEN, focusing on the above-noted "grey areas".
KW - Appendiceal Neoplasms/diagnosis
KW - Biomedical Research/trends
KW - Guidelines as Topic
KW - Humans
KW - Neuroendocrine Tumors/diagnosis
KW - Prognosis
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058168315&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30235454
U2 - https://doi.org/10.1159/000493894
DO - https://doi.org/10.1159/000493894
M3 - Review article
C2 - 30235454
SN - 0028-3835
VL - 108
SP - 37
EP - 44
JO - Neuroendocrinology
JF - Neuroendocrinology
IS - 1
ER -