TY - JOUR
T1 - Unraveling the genetic etiology of adult antisocial behavior: A genome-wide association study
AU - Tielbeek, J.J.
AU - Medland, S.E.
AU - Benyamin, B.
AU - Byrne, E.M.
AU - Heath, A.C.
AU - Madden, P.A.F.
AU - Martin, N.G.
AU - Wray, N.R.
AU - Verweij, K.J.H.
PY - 2012
Y1 - 2012
N2 - Crime poses a major burden for society. The heterogeneous nature of criminal behavior makes it difficult to unravel its causes. Relatively little research has been conducted on the genetic influences of criminal behavior. The few twin and adoption studies that have been undertaken suggest that about half of the variance in antisocial behavior can be explained by genetic factors. In order to identify the specific common genetic variants underlying this behavior, we conduct the first genome-wide association study (GWAS) on adult antisocial behavior. Our sample comprised a community sample of 4816 individuals who had completed a self-report questionnaire. No genetic polymorphisms reached genome-wide significance for association with adult antisocial behavior. In addition, none of the traditional candidate genes can be confirmed in our study. While not genome-wide significant, the gene with the strongest association (p-value = 8.7×10
AB - Crime poses a major burden for society. The heterogeneous nature of criminal behavior makes it difficult to unravel its causes. Relatively little research has been conducted on the genetic influences of criminal behavior. The few twin and adoption studies that have been undertaken suggest that about half of the variance in antisocial behavior can be explained by genetic factors. In order to identify the specific common genetic variants underlying this behavior, we conduct the first genome-wide association study (GWAS) on adult antisocial behavior. Our sample comprised a community sample of 4816 individuals who had completed a self-report questionnaire. No genetic polymorphisms reached genome-wide significance for association with adult antisocial behavior. In addition, none of the traditional candidate genes can be confirmed in our study. While not genome-wide significant, the gene with the strongest association (p-value = 8.7×10
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867504483&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/23077488
U2 - https://doi.org/10.1371/journal.pone.0045086
DO - https://doi.org/10.1371/journal.pone.0045086
M3 - Article
C2 - 23077488
SN - 1932-6203
VL - 7
JO - PLOS ONE
JF - PLOS ONE
IS - 10
M1 - e45086
ER -