TY - JOUR
T1 - Uraemic symptom burden and clinical condition in women and men of ≥65 years of age with advanced chronic kidney disease: Results from the EQUAL study
AU - van de Luijtgaarden, Moniek W. M.
AU - Caskey, Fergus J.
AU - Wanner, Christoph
AU - Chesnaye, Nicholas C.
AU - Postorino, Maurizio
AU - Janmaat, Cynthia J.
AU - Rao, Anirudh
AU - Torino, Claudia
AU - Klinger, Marian
AU - Drechsler, Christiane
AU - Heimburger, Olof
AU - Szymczak, Maciej
AU - Evans, Marie
AU - Dekker, Friedo W.
AU - Jager, Kitty J.
AU - EQUAL Study Investigators
AU - Adamasco Cupisti, I. T.
AU - Adelia Sagliocca, I. T.
AU - Alberto Ferraro, I. T.
AU - Aleksandra Musiała, P. L.
AU - Alessandra Mele, I. T.
AU - Alessandro Naticchia, I. T.
AU - Alex Còsaro, I. T.
AU - Alistair Woodman, U. K.
AU - Andrea Ranghino, I. T.
AU - Andrea Stucchi, I. T.
AU - Andreas Jonsson, S. E.
AU - Andreas Schneider, D. E.
AU - Angelo Pignataro, I. T.
AU - Anita Schrander, N. L.
AU - Anke Torp, D. E.
AU - Anna McKeever, U. K.
AU - Anna Szymczak, P. L.
AU - Anna-Lena Blom, S. E.
AU - Antonella de Blasio, I. T.
AU - Antonello Pani, I. T.
AU - Aris Tsalouichos, I. T.
AU - Asad Ullah, U. K.
AU - Barbara McLaren, U. K.
AU - Bastiaan van Dam, N. L.
AU - Beate Iwig, D. E.
AU - Bellasi Antonio, I. T.
AU - Biagio Raffaele di Iorio, I. T.
AU - Björn Rogland, S. E.
AU - Boris Perras, D. E.
AU - Butti Alessandra, I. T.
AU - Camille Harron, U. K.
AU - Carin Wallquist, S. E.
AU - Carl Siegert, N. L.
AU - Carla Barrett, U. K.
AU - Carlo Gaillard, N. L.
PY - 2019
Y1 - 2019
N2 - Background. The epidemiology and prognosis of chronic kidney disease (CKD) differ by sex. We aimed to compare symptom prevalence and the clinical state in women and men of ≥65 years of age with advanced CKD receiving routine nephrology care. Methods. The European QUALity study on treatment in advanced chronic kidney disease (EQUAL) study follows patients from six European countries of ≥65 years of age years whose estimated glomerular filtration rate (eGFR) dropped to ≤20 mL/min/ 1.73 m2 for the first time during the last 6 months. The Dialysis Symptom Index was used to assess the prevalence and severity of 33 uraemic symptoms. Data on the clinical state at baseline were collected from medical records. Prevalence was standardized using the age distribution of women as the reference. Results. The results in women (n = 512) and men (n = 967) did not differ with age (77.0 versus 75.7 years) or eGFR (19.0 versus 18.5). The median number of symptoms was 14 [interquartile range (IQR) 9–19] in women, and 11 (IQR 7–16) in men. Women most frequently reported fatigue {39% [95% confidence interval (CI) 34–45]} and bone/joint pain [37% (95% CI 32–42)] as severe symptoms, whereas more men reported difficulty in becoming sexually aroused [32% (95% CI 28–35)] and a decreased interest in sex [31% (95% CI 28–35)]. Anaemia [73% (95% CI 69–77) versus 85% (95% CI 82–87)] was less common in women than in men, as were smoking history and cardiovascular comorbidity. However, a diagnosis of liver disease other than cirrhosis, psychiatric disease and mild malnutrition were more common among women. Conclusions. Women in secondary care with an incident eGFR ≤20 mL/min/1.73 m2 reported a higher symptom burden, while their clinical state was considered similar or even more favourable as compared with men.
AB - Background. The epidemiology and prognosis of chronic kidney disease (CKD) differ by sex. We aimed to compare symptom prevalence and the clinical state in women and men of ≥65 years of age with advanced CKD receiving routine nephrology care. Methods. The European QUALity study on treatment in advanced chronic kidney disease (EQUAL) study follows patients from six European countries of ≥65 years of age years whose estimated glomerular filtration rate (eGFR) dropped to ≤20 mL/min/ 1.73 m2 for the first time during the last 6 months. The Dialysis Symptom Index was used to assess the prevalence and severity of 33 uraemic symptoms. Data on the clinical state at baseline were collected from medical records. Prevalence was standardized using the age distribution of women as the reference. Results. The results in women (n = 512) and men (n = 967) did not differ with age (77.0 versus 75.7 years) or eGFR (19.0 versus 18.5). The median number of symptoms was 14 [interquartile range (IQR) 9–19] in women, and 11 (IQR 7–16) in men. Women most frequently reported fatigue {39% [95% confidence interval (CI) 34–45]} and bone/joint pain [37% (95% CI 32–42)] as severe symptoms, whereas more men reported difficulty in becoming sexually aroused [32% (95% CI 28–35)] and a decreased interest in sex [31% (95% CI 28–35)]. Anaemia [73% (95% CI 69–77) versus 85% (95% CI 82–87)] was less common in women than in men, as were smoking history and cardiovascular comorbidity. However, a diagnosis of liver disease other than cirrhosis, psychiatric disease and mild malnutrition were more common among women. Conclusions. Women in secondary care with an incident eGFR ≤20 mL/min/1.73 m2 reported a higher symptom burden, while their clinical state was considered similar or even more favourable as compared with men.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068705822&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29905848
U2 - https://doi.org/10.1093/ndt/gfy155
DO - https://doi.org/10.1093/ndt/gfy155
M3 - Article
C2 - 29905848
SN - 0931-0509
VL - 34
SP - 1
EP - 8
JO - Nephrology, dialysis, transplantation
JF - Nephrology, dialysis, transplantation
IS - 7
ER -