TY - JOUR
T1 - Ursodeoxycholic acid in pregnancy?
AU - de Vries, Elsemieke
AU - Beuers, Ulrich
PY - 2019
Y1 - 2019
N2 - The case of a 34-year-old woman with primary biliary cholangitis (PBC) before, during and after pregnancy is described. The use of ursodeoxycholic acid (UDCA) during and after pregnancy is discussed. UDCA has not been approved by the drug regulatory authorities as a pregnancy-safe drug; therefore, the reluctance of clinicians to prescribe UDCA during pregnancy is understandable. This Grand Round aims to provide a detailed analysis of the current evidence, safety data and clinical experience with UDCA (and alternative drugs) during pregnancy and lactation. Based on this analysis, advice for clinicians regarding the use of UDCA during pregnancy and lactation is given.
AB - The case of a 34-year-old woman with primary biliary cholangitis (PBC) before, during and after pregnancy is described. The use of ursodeoxycholic acid (UDCA) during and after pregnancy is discussed. UDCA has not been approved by the drug regulatory authorities as a pregnancy-safe drug; therefore, the reluctance of clinicians to prescribe UDCA during pregnancy is understandable. This Grand Round aims to provide a detailed analysis of the current evidence, safety data and clinical experience with UDCA (and alternative drugs) during pregnancy and lactation. Based on this analysis, advice for clinicians regarding the use of UDCA during pregnancy and lactation is given.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074435596&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31479696
U2 - https://doi.org/10.1016/j.jhep.2019.08.020
DO - https://doi.org/10.1016/j.jhep.2019.08.020
M3 - Review article
C2 - 31479696
SN - 0168-8278
VL - 71
SP - 1237
EP - 1245
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 6
ER -