Use of a new monoclonal antibody-based enzyme immunoassay for soluble fibrin to exclude pulmonary embolism. ANTELOPE-Study Group

M. R. Mac Gillavry; B. J. Sanson; W. de Monyé; J. G. Lijmer; M. V. Huisman; H. R. Büller; W. Nieuwenhuizen; D. P. Brandjes; M. H. Prins; P. M.T. Pattynama; M. J.L. Van Strijen; G. J. Kieft; M. De Rijk; P. J. Hagen; O. S. Hoekstra; P. E. Postmus; I. J.C. Hartmann; J. D. Banga; P. F.G.M. Van Waes

doi:https://doi.org/10.1055/s-0037-1614047

Use of a new monoclonal antibody-based enzyme immunoassay for soluble fibrin to exclude pulmonary embolism. ANTELOPE-Study Group

M. R. Mac Gillavry, B. J. Sanson, W. de Monyé, J. G. Lijmer, M. V. Huisman, H. R. Büller, W. Nieuwenhuizen, D. P. Brandjes, M. H. Prins, P. M.T. Pattynama, M. J.L. Van Strijen, G. J. Kieft, M. De Rijk, P. J. Hagen, O. S. Hoekstra, P. E. Postmus, I. J.C. Hartmann, J. D. Banga, P. F.G.M. Van Waes

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Abstract

We prospectively evaluated the diagnostic performance of a new soluble fibrin assay in 303 consecutive patients with suspected pulmonary embolism and examined potentially useful cut-off levels at which this disease can be safely excluded. In addition, the diagnostic accuracy was calculated in the subgroups of in- and outpatients. The ROC curve of the assay in the total study cohort had an area under the curve of 0.69. The cut-off level associated with a sensitivity and negative predictive value of 100% was 20 ng/ml, but the specificity was only 4%. The cut-off level with a sensitivity of 90% was 30 ng/ml, which corresponded with a specificity and negative predictive value of 27% and 86%. respectively. The diagnostic performance was comparable in the subgroups of in- and outpatients. We conclude that the soluble fibrin assay has a low diagnostic accuracy and seems unsuitable as a screening test for the exclusion of pulmonary embolism

Original language	English
Pages (from-to)	474-477
Number of pages	4
Journal	Thrombosis and haemostasis
Volume	84
Issue number	3
DOIs	https://doi.org/10.1055/s-0037-1614047
Publication status	Published - 2000

Keywords

Diagnosis
Pulmonary embolism
Soluble fibrin

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Mac Gillavry, M. R., Sanson, B. J., de Monyé, W., Lijmer, J. G., Huisman, M. V., Büller, H. R., Nieuwenhuizen, W., Brandjes, D. P., Prins, M. H., Pattynama, P. M. T., Van Strijen, M. J. L., Kieft, G. J., De Rijk, M., Hagen, P. J., Hoekstra, O. S., Postmus, P. E., Hartmann, I. J. C., Banga, J. D., & Van Waes, P. F. G. M. (2000). Use of a new monoclonal antibody-based enzyme immunoassay for soluble fibrin to exclude pulmonary embolism. ANTELOPE-Study Group. Thrombosis and haemostasis, 84(3), 474-477. https://doi.org/10.1055/s-0037-1614047

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title = "Use of a new monoclonal antibody-based enzyme immunoassay for soluble fibrin to exclude pulmonary embolism. ANTELOPE-Study Group",

abstract = "We prospectively evaluated the diagnostic performance of a new soluble fibrin assay in 303 consecutive patients with suspected pulmonary embolism and examined potentially useful cut-off levels at which this disease can be safely excluded. In addition, the diagnostic accuracy was calculated in the subgroups of in- and outpatients. The ROC curve of the assay in the total study cohort had an area under the curve of 0.69. The cut-off level associated with a sensitivity and negative predictive value of 100% was 20 ng/ml, but the specificity was only 4%. The cut-off level with a sensitivity of 90% was 30 ng/ml, which corresponded with a specificity and negative predictive value of 27% and 86%. respectively. The diagnostic performance was comparable in the subgroups of in- and outpatients. We conclude that the soluble fibrin assay has a low diagnostic accuracy and seems unsuitable as a screening test for the exclusion of pulmonary embolism",

keywords = "Diagnosis, Pulmonary embolism, Soluble fibrin",

author = "{Mac Gillavry}, {M. R.} and Sanson, {B. J.} and {de Mony{\'e}}, W. and Lijmer, {J. G.} and Huisman, {M. V.} and B{\"u}ller, {H. R.} and W. Nieuwenhuizen and Brandjes, {D. P.} and Prins, {M. H.} and Pattynama, {P. M.T.} and {Van Strijen}, {M. J.L.} and Kieft, {G. J.} and {De Rijk}, M. and Hagen, {P. J.} and Hoekstra, {O. S.} and Postmus, {P. E.} and Hartmann, {I. J.C.} and Banga, {J. D.} and {Van Waes}, {P. F.G.M.}",

year = "2000",

doi = "https://doi.org/10.1055/s-0037-1614047",

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Mac Gillavry, MR, Sanson, BJ, de Monyé, W, Lijmer, JG, Huisman, MV, Büller, HR, Nieuwenhuizen, W, Brandjes, DP, Prins, MH, Pattynama, PMT, Van Strijen, MJL, Kieft, GJ, De Rijk, M, Hagen, PJ, Hoekstra, OS, Postmus, PE, Hartmann, IJC, Banga, JD & Van Waes, PFGM 2000, 'Use of a new monoclonal antibody-based enzyme immunoassay for soluble fibrin to exclude pulmonary embolism. ANTELOPE-Study Group', Thrombosis and haemostasis, vol. 84, no. 3, pp. 474-477. https://doi.org/10.1055/s-0037-1614047

TY - JOUR

T1 - Use of a new monoclonal antibody-based enzyme immunoassay for soluble fibrin to exclude pulmonary embolism. ANTELOPE-Study Group

AU - Mac Gillavry, M. R.

AU - Sanson, B. J.

AU - de Monyé, W.

AU - Lijmer, J. G.

AU - Huisman, M. V.

AU - Büller, H. R.

AU - Nieuwenhuizen, W.

AU - Brandjes, D. P.

AU - Prins, M. H.

AU - Pattynama, P. M.T.

AU - Van Strijen, M. J.L.

AU - Kieft, G. J.

AU - De Rijk, M.

AU - Hagen, P. J.

AU - Hoekstra, O. S.

AU - Postmus, P. E.

AU - Hartmann, I. J.C.

AU - Banga, J. D.

AU - Van Waes, P. F.G.M.

PY - 2000

Y1 - 2000

N2 - We prospectively evaluated the diagnostic performance of a new soluble fibrin assay in 303 consecutive patients with suspected pulmonary embolism and examined potentially useful cut-off levels at which this disease can be safely excluded. In addition, the diagnostic accuracy was calculated in the subgroups of in- and outpatients. The ROC curve of the assay in the total study cohort had an area under the curve of 0.69. The cut-off level associated with a sensitivity and negative predictive value of 100% was 20 ng/ml, but the specificity was only 4%. The cut-off level with a sensitivity of 90% was 30 ng/ml, which corresponded with a specificity and negative predictive value of 27% and 86%. respectively. The diagnostic performance was comparable in the subgroups of in- and outpatients. We conclude that the soluble fibrin assay has a low diagnostic accuracy and seems unsuitable as a screening test for the exclusion of pulmonary embolism

AB - We prospectively evaluated the diagnostic performance of a new soluble fibrin assay in 303 consecutive patients with suspected pulmonary embolism and examined potentially useful cut-off levels at which this disease can be safely excluded. In addition, the diagnostic accuracy was calculated in the subgroups of in- and outpatients. The ROC curve of the assay in the total study cohort had an area under the curve of 0.69. The cut-off level associated with a sensitivity and negative predictive value of 100% was 20 ng/ml, but the specificity was only 4%. The cut-off level with a sensitivity of 90% was 30 ng/ml, which corresponded with a specificity and negative predictive value of 27% and 86%. respectively. The diagnostic performance was comparable in the subgroups of in- and outpatients. We conclude that the soluble fibrin assay has a low diagnostic accuracy and seems unsuitable as a screening test for the exclusion of pulmonary embolism

KW - Diagnosis

KW - Pulmonary embolism

KW - Soluble fibrin

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U2 - https://doi.org/10.1055/s-0037-1614047

DO - https://doi.org/10.1055/s-0037-1614047

M3 - Article

C2 - 11019974

SN - 0340-6245

VL - 84

SP - 474

EP - 477

JO - Thrombosis and haemostasis

JF - Thrombosis and haemostasis

IS - 3

ER -

Use of a new monoclonal antibody-based enzyme immunoassay for soluble fibrin to exclude pulmonary embolism. ANTELOPE-Study Group

Abstract

Keywords

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