Use of bi-allelic insertion/deletion polymorphisms as a positive control for fetal genotyping in maternal blood: first clinical experience

Godelieve C. M. L. Page-Christiaens; Bernadette Bossers; C. Ellen van der Schoot; Masja de Haas

doi:https://doi.org/10.1196/annals.1368.016

Use of bi-allelic insertion/deletion polymorphisms as a positive control for fetal genotyping in maternal blood: first clinical experience

Godelieve C. M. L. Page-Christiaens, Bernadette Bossers, C. Ellen van der Schoot, Masja de Haas

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Abstract

Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal "disease" sequence

Original language	English
Pages (from-to)	123-129
Journal	Annals of the New York Academy of Sciences
Volume	1075
DOIs	https://doi.org/10.1196/annals.1368.016
Publication status	Published - 2006

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https://doi.org/10.1196/annals.1368.016

Cite this

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abstract = "Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal {"}disease{"} sequence",

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Use of bi-allelic insertion/deletion polymorphisms as a positive control for fetal genotyping in maternal blood: first clinical experience. / Page-Christiaens, Godelieve C. M. L.; Bossers, Bernadette; van der Schoot, C. Ellen et al.
In: Annals of the New York Academy of Sciences, Vol. 1075, 2006, p. 123-129.

Research output: Contribution to journal › Article › Academic › peer-review

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AB - Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal "disease" sequence

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