TY - JOUR
T1 - Use of bone morphogenetic proteins in traumatology
AU - Westerhuis, R. J.
AU - van Bezooijen, R. L.
AU - Kloen, P.
PY - 2005
Y1 - 2005
N2 - An estimated 5-10% of all fractures show impaired heating, leading to delayed union, or non-union. Chemical, or physical methods to accelerate bone heating are of great interest to the orthopaedic and trauma community. Research over the last 20 years has established that successful fracture heating is steered by specific growth factors. Of these, the bone morphogenetic proteins (BMPs) are probably the most important. The signalling pathway of these proteins is tightly regulated, overseeing a finely orchestrated cascade of events that occur after a fracture. The promising results of BMPs in preclinical studies have recently cleared the way for their use in specific fractures, or non-unions in clinical practice. The purpose of this work is to give a brief overview of BMPs and to review the clinical data currently available on the use of BMPs in fracture heating. (c) 2005 Elsevier Ltd. All rights reserved
AB - An estimated 5-10% of all fractures show impaired heating, leading to delayed union, or non-union. Chemical, or physical methods to accelerate bone heating are of great interest to the orthopaedic and trauma community. Research over the last 20 years has established that successful fracture heating is steered by specific growth factors. Of these, the bone morphogenetic proteins (BMPs) are probably the most important. The signalling pathway of these proteins is tightly regulated, overseeing a finely orchestrated cascade of events that occur after a fracture. The promising results of BMPs in preclinical studies have recently cleared the way for their use in specific fractures, or non-unions in clinical practice. The purpose of this work is to give a brief overview of BMPs and to review the clinical data currently available on the use of BMPs in fracture heating. (c) 2005 Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.injury.2005.02.047
DO - https://doi.org/10.1016/j.injury.2005.02.047
M3 - Review article
C2 - 16125704
SN - 0020-1383
VL - 36
SP - 1405
EP - 1412
JO - Injury
JF - Injury
IS - 12
ER -