TY - JOUR
T1 - Usefulness of mean corpuscular volume as a surrogate marker for monitoring thiopurine treatment in inflammatory bowel disease
AU - Dujardin, Romein W. G.
AU - Meijer, Berrie
AU - de Boer, Nanne K. H.
AU - D'Haens, Geert R.
AU - Löwenberg, Mark
PY - 2016/9
Y1 - 2016/9
N2 - Thiopurines are commonly used drugs in inflammatory bowel disease. Intracellular levels of thiopurine metabolites [i.e. 6-thioguaninenucleotides (6-TGN)] are associated with efficacy and toxicity. Because 6-TGN measurement is not globally available, the mean corpuscular volume (MCV) has been proposed as a surrogate marker for monitoring thiopurine therapy. To analyze the relationship between MCV and efficacy of thiopurines, defined as either response to therapy or 6-TGN levels. A systematic search on PubMed was performed. Fifteen studies were included. In six studies, a positive association was found between ΔMCV and 6-TGN. In four studies, it was suggested that ΔMCV can be used to predict clinical remission. In five articles, no association was found. In the majority of articles, it was reported that ΔMCV is useful in guiding intracellular metabolite levels. However, there is insufficient evidence showing that ΔMCV can predict clinical remission
AB - Thiopurines are commonly used drugs in inflammatory bowel disease. Intracellular levels of thiopurine metabolites [i.e. 6-thioguaninenucleotides (6-TGN)] are associated with efficacy and toxicity. Because 6-TGN measurement is not globally available, the mean corpuscular volume (MCV) has been proposed as a surrogate marker for monitoring thiopurine therapy. To analyze the relationship between MCV and efficacy of thiopurines, defined as either response to therapy or 6-TGN levels. A systematic search on PubMed was performed. Fifteen studies were included. In six studies, a positive association was found between ΔMCV and 6-TGN. In four studies, it was suggested that ΔMCV can be used to predict clinical remission. In five articles, no association was found. In the majority of articles, it was reported that ΔMCV is useful in guiding intracellular metabolite levels. However, there is insufficient evidence showing that ΔMCV can predict clinical remission
KW - Journal Article
U2 - https://doi.org/10.1097/MEG.0000000000000675
DO - https://doi.org/10.1097/MEG.0000000000000675
M3 - Review article
C2 - 27257870
SN - 0954-691X
VL - 28
SP - 991
EP - 996
JO - European Journal of Gastroenterology & Hepatology
JF - European Journal of Gastroenterology & Hepatology
IS - 9
ER -