Using the glycan toolbox for pathogenic interventions and glycan immunotherapy

Research output: Contribution to journalReview articleAcademicpeer-review

25 Citations (Scopus)


Glycans play a crucial role to discern between self and foreign entities by providing key recognition elements for C-type lectin receptors (CLRs) and Siglec receptors expressed on immune cells. The glycan recognition of CLRs has illustrated a potent immune modulatory role affecting not only innate pathogen binding and immune signalling, but also Thelper differentiation, cytokine production and antigen presentation. This broad range of influence has implicated glycans in the pathogenesis of infectious diseases but also revealed their extraordinary properties in cancer. Glycan binding by CLRs and Siglecs can be exploited for immunotherapy and the design of glycan-based therapeutics and their multivalent requirements will aspire new biotechnological approaches to effectively interfere in immunological processes in cancer and infectious diseases.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalCurrent opinion in biotechnology
Early online date22 Nov 2017
Publication statusPublished - 1 Jun 2018


  • Journal Article
  • Review

Cite this