Uterine carcinosarcoma with melanocytic differentiation

F. Amant; P. Moerman; G. H. Davel; R. de Vos; I. Vergote; B. G. Lindeque; E. de Jonge

doi:https://doi.org/10.1097/00004347-200104000-00012

Uterine carcinosarcoma with melanocytic differentiation

F. Amant, P. Moerman, G. H. Davel, R. de Vos, I. Vergote, B. G. Lindeque, E. de Jonge

Amsterdam UMC

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

A 65-year-old black woman was found to have a 3.0 cm endometrial tumor that was a carcinosarcoma with a major epithelial and a less prominent mesenchymal component. The latter was undifferentiated but one focus of chondroid differentiation was noted. The former showed papillary serous differentiation. Melanin pigment was observed in both epithelial and mesenchymal components. Staining with antisera to S100 protein and HMB-45 confirmed the presence of melanocytes. An endocervical focus of tumor also contained melanin. Electron-microscopic studies showed large tumor cells with an irregularly indented nucleus and abnormal giant cytoplasmic melanosomes. Only one case of uterine carcinosarcoma with melanocytic differentiation has been previously reported

Original language	English
Pages (from-to)	186-190
Journal	International Journal of Gynecological Pathology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1097/00004347-200104000-00012
Publication status	Published - 2001

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https://doi.org/10.1097/00004347-200104000-00012

Cite this

@article{f6404fcb13184f0e946da1e781f10fea,

title = "Uterine carcinosarcoma with melanocytic differentiation",

abstract = "A 65-year-old black woman was found to have a 3.0 cm endometrial tumor that was a carcinosarcoma with a major epithelial and a less prominent mesenchymal component. The latter was undifferentiated but one focus of chondroid differentiation was noted. The former showed papillary serous differentiation. Melanin pigment was observed in both epithelial and mesenchymal components. Staining with antisera to S100 protein and HMB-45 confirmed the presence of melanocytes. An endocervical focus of tumor also contained melanin. Electron-microscopic studies showed large tumor cells with an irregularly indented nucleus and abnormal giant cytoplasmic melanosomes. Only one case of uterine carcinosarcoma with melanocytic differentiation has been previously reported",

author = "F. Amant and P. Moerman and Davel, {G. H.} and {de Vos}, R. and I. Vergote and Lindeque, {B. G.} and {de Jonge}, E.",

year = "2001",

doi = "https://doi.org/10.1097/00004347-200104000-00012",

language = "English",

volume = "20",

pages = "186--190",

journal = "International Journal of Gynecological Pathology",

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TY - JOUR

T1 - Uterine carcinosarcoma with melanocytic differentiation

AU - Amant, F.

AU - Moerman, P.

AU - Davel, G. H.

AU - de Vos, R.

AU - Vergote, I.

AU - Lindeque, B. G.

AU - de Jonge, E.

PY - 2001

Y1 - 2001

N2 - A 65-year-old black woman was found to have a 3.0 cm endometrial tumor that was a carcinosarcoma with a major epithelial and a less prominent mesenchymal component. The latter was undifferentiated but one focus of chondroid differentiation was noted. The former showed papillary serous differentiation. Melanin pigment was observed in both epithelial and mesenchymal components. Staining with antisera to S100 protein and HMB-45 confirmed the presence of melanocytes. An endocervical focus of tumor also contained melanin. Electron-microscopic studies showed large tumor cells with an irregularly indented nucleus and abnormal giant cytoplasmic melanosomes. Only one case of uterine carcinosarcoma with melanocytic differentiation has been previously reported

AB - A 65-year-old black woman was found to have a 3.0 cm endometrial tumor that was a carcinosarcoma with a major epithelial and a less prominent mesenchymal component. The latter was undifferentiated but one focus of chondroid differentiation was noted. The former showed papillary serous differentiation. Melanin pigment was observed in both epithelial and mesenchymal components. Staining with antisera to S100 protein and HMB-45 confirmed the presence of melanocytes. An endocervical focus of tumor also contained melanin. Electron-microscopic studies showed large tumor cells with an irregularly indented nucleus and abnormal giant cytoplasmic melanosomes. Only one case of uterine carcinosarcoma with melanocytic differentiation has been previously reported

U2 - https://doi.org/10.1097/00004347-200104000-00012

DO - https://doi.org/10.1097/00004347-200104000-00012

M3 - Article

C2 - 11293166

SN - 0277-1691

VL - 20

SP - 186

EP - 190

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

IS - 2

ER -