Vaccine Preventability of Meningococcal Clone, Greater Aachen Region, Germany

J. Elias; L.M. Schouls; I. van de Pol; W.C. Keijzers; D.R. Martin; A. Glennie; P. Oster; M. Frosch; U. Vogel; A. van den Ende; Arie van der Ende

doi:https://doi.org/10.3201/eid1603.091102

Vaccine Preventability of Meningococcal Clone, Greater Aachen Region, Germany

J. Elias, L.M. Schouls, I. van de Pol, W.C. Keijzers, D.R. Martin, A. Glennie, P. Oster, M. Frosch, U. Vogel, A. van den Ende, Arie van der Ende

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Abstract

Emergence of serogroup B meningococci of clonal complex sequence type (ST) 41/44 can cause high levels of disease, as exemplified by a recent epidemic in New Zealand. Multiplication of annual incidence rates (3.1 cases/100,000 population) of meningococcal disease in a defined German region, the city of Aachen and 3 neighboring countries (Greater Aachen) prompted us to investigate and determine the source and nature of this outbreak. Using molecular typing and geographic mapping, we analyzed 1,143 strains belonging to ST41/44 complex, isolated from persons with invasive meningococcal disease over 6 years (2001-2006) from 2 German federal states (total population 26 million) and the Netherlands. A spatially slowly moving clone with multiple-locus variable-number tandem repeat analysis type 19, ST42, and antigenic profile B:P1.7-2,4:F1-5 was responsible for the outbreak. Bactericidal activity in serum samples from the New Zealand MeNZB vaccination campaign confirmed vaccine preventability. Because this globally distributed epidemic strain spreads slowly, vaccination efforts could possibly eliminate meningococcal disease in this area

Original language	Undefined/Unknown
Pages (from-to)	464-472
Journal	Emerging infectious diseases
Volume	16
Issue number	3
DOIs	https://doi.org/10.3201/eid1603.091102
Publication status	Published - 2010

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https://doi.org/10.3201/eid1603.091102

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Cite this

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title = "Vaccine Preventability of Meningococcal Clone, Greater Aachen Region, Germany",

abstract = "Emergence of serogroup B meningococci of clonal complex sequence type (ST) 41/44 can cause high levels of disease, as exemplified by a recent epidemic in New Zealand. Multiplication of annual incidence rates (3.1 cases/100,000 population) of meningococcal disease in a defined German region, the city of Aachen and 3 neighboring countries (Greater Aachen) prompted us to investigate and determine the source and nature of this outbreak. Using molecular typing and geographic mapping, we analyzed 1,143 strains belonging to ST41/44 complex, isolated from persons with invasive meningococcal disease over 6 years (2001-2006) from 2 German federal states (total population 26 million) and the Netherlands. A spatially slowly moving clone with multiple-locus variable-number tandem repeat analysis type 19, ST42, and antigenic profile B:P1.7-2,4:F1-5 was responsible for the outbreak. Bactericidal activity in serum samples from the New Zealand MeNZB vaccination campaign confirmed vaccine preventability. Because this globally distributed epidemic strain spreads slowly, vaccination efforts could possibly eliminate meningococcal disease in this area",

author = "J. Elias and L.M. Schouls and {van de Pol}, I. and W.C. Keijzers and D.R. Martin and A. Glennie and P. Oster and M. Frosch and U. Vogel and {van den Ende}, A. and {van der Ende}, Arie",

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AU - Elias, J.

AU - Schouls, L.M.

AU - van de Pol, I.

AU - Keijzers, W.C.

AU - Martin, D.R.

AU - Glennie, A.

AU - Oster, P.

AU - Frosch, M.

AU - Vogel, U.

AU - van den Ende, A.

AU - van der Ende, Arie

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AB - Emergence of serogroup B meningococci of clonal complex sequence type (ST) 41/44 can cause high levels of disease, as exemplified by a recent epidemic in New Zealand. Multiplication of annual incidence rates (3.1 cases/100,000 population) of meningococcal disease in a defined German region, the city of Aachen and 3 neighboring countries (Greater Aachen) prompted us to investigate and determine the source and nature of this outbreak. Using molecular typing and geographic mapping, we analyzed 1,143 strains belonging to ST41/44 complex, isolated from persons with invasive meningococcal disease over 6 years (2001-2006) from 2 German federal states (total population 26 million) and the Netherlands. A spatially slowly moving clone with multiple-locus variable-number tandem repeat analysis type 19, ST42, and antigenic profile B:P1.7-2,4:F1-5 was responsible for the outbreak. Bactericidal activity in serum samples from the New Zealand MeNZB vaccination campaign confirmed vaccine preventability. Because this globally distributed epidemic strain spreads slowly, vaccination efforts could possibly eliminate meningococcal disease in this area

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