Van gen naar ziekte; ionkanaaleiwitten en het lange-QT-intervalsyndroom

A. A. Wilde, I. M. van Langen

Research output: Contribution to journalArticleProfessional

Abstract

The long QT syndrome is characterised by QT prolongation on the ECG, repeated syncope and sudden cardiac death. QT prolongation is the result of delayed repolarisation at the cellular level, secondary to dysfunctioning ion channels. Ventricular arrhythmias underlie syncope and death. At least six genes, all encoding (parts of) ion channels, are causally involved. A molecular diagnosis is often feasible and can be reached reasonably straightforwardly, based on the clinical (family) history and the ECG pattern
Original languageDutch
Pages (from-to)2205-2207
JournalNederlands Tijdschrift voor Geneeskunde
Volume144
Issue number46
Publication statusPublished - 2000

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