Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Steve Turner; Ben Francis; Nuha Wani; Susanne Vijverberg; Maria Pino-Yanes; Somnath Mukhopadhyay; Roger Tavendale; Colin Palmer; Esteban G. Burchard; Simon Kebede Merid; Erik Melén; Anke H. Maitland-van der Zee

doi:https://doi.org/10.2217/pgs-2018-0027

Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Steve Turner, Ben Francis, Nuha Wani, Susanne Vijverberg, Maria Pino-Yanes, Somnath Mukhopadhyay, Roger Tavendale, Colin Palmer, Esteban G. Burchard, Simon Kebede Merid, Erik Melén, Anke H. Maitland-van der Zee

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

Original language	English
Pages (from-to)	707-713
Journal	Pharmacogenomics
Volume	19
Issue number	8
DOIs	https://doi.org/10.2217/pgs-2018-0027
Publication status	Published - 2018

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title = "Variants in genes coding for glutathione S-transferases and asthma outcomes in children",

abstract = "Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.",

author = "Steve Turner and Ben Francis and Nuha Wani and Susanne Vijverberg and Maria Pino-Yanes and Somnath Mukhopadhyay and Roger Tavendale and Colin Palmer and Burchard, {Esteban G.} and Merid, {Simon Kebede} and Erik Mel{\'e}n and {Maitland-van der Zee}, {Anke H.}",

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T1 - Variants in genes coding for glutathione S-transferases and asthma outcomes in children

AU - Turner, Steve

AU - Francis, Ben

AU - Wani, Nuha

AU - Vijverberg, Susanne

AU - Pino-Yanes, Maria

AU - Mukhopadhyay, Somnath

AU - Tavendale, Roger

AU - Palmer, Colin

AU - Burchard, Esteban G.

AU - Merid, Simon Kebede

AU - Melén, Erik

AU - Maitland-van der Zee, Anke H.

PY - 2018

Y1 - 2018

N2 - Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

AB - Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29785881

U2 - https://doi.org/10.2217/pgs-2018-0027

DO - https://doi.org/10.2217/pgs-2018-0027

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SN - 1462-2416

VL - 19

SP - 707

EP - 713

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 8

ER -

Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Abstract

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