TY - CHAP
T1 - Vascular Endothelial Cell Dysfunction in Preeclampsia
AU - Goulopoulou, Styliani
AU - de Groot, Christianne
AU - Taylor, Robert N.
AU - Davidge, Sandra T.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - In the early 1980s, physicians and scientists began to gain an appreciation of the physiological importance of the endothelium, the simple unicellular layer lining the luminal surface of blood vessels. Indeed, in Chesley’s first, single-authored edition of this text, the reference to this term was confined to the “endotheliosis” lesion of the renal glomerulus. We now recognize that endothelial cells are critical sensors of the milieu interieur and potent regulators of vascular tone, organ perfusion, and ischemia. The “endothelial hypothesis” of preeclampsia etiology provides for a convergence of several factors thought to play fundamental roles in its pathogenesis: leukocytes, platelets, cytokines, fatty acids, oxygen free radicals, placental microvesicles, cell-free DNA fragments, “antiangiogenic” factors, and autoantibodies are all considered.
AB - In the early 1980s, physicians and scientists began to gain an appreciation of the physiological importance of the endothelium, the simple unicellular layer lining the luminal surface of blood vessels. Indeed, in Chesley’s first, single-authored edition of this text, the reference to this term was confined to the “endotheliosis” lesion of the renal glomerulus. We now recognize that endothelial cells are critical sensors of the milieu interieur and potent regulators of vascular tone, organ perfusion, and ischemia. The “endothelial hypothesis” of preeclampsia etiology provides for a convergence of several factors thought to play fundamental roles in its pathogenesis: leukocytes, platelets, cytokines, fatty acids, oxygen free radicals, placental microvesicles, cell-free DNA fragments, “antiangiogenic” factors, and autoantibodies are all considered.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85130670418&origin=inward
U2 - https://doi.org/10.1016/B978-0-12-818417-2.00006-3
DO - https://doi.org/10.1016/B978-0-12-818417-2.00006-3
M3 - Chapter
SN - 9780128184189
T3 - Chesley’s Hypertensive Disorders in Pregnancy
SP - 187
EP - 218
BT - Chesley’s Hypertensive Disorders in Pregnancy
PB - Elsevier
ER -