TY - JOUR
T1 - Ventilation practices in burn patients - an international prospective observational cohort study
AU - LAMiNAR investigators
AU - Schultz, Marcus J
AU - Horn, Janneke
AU - Hollmann, Markus W
AU - Preckel, Benedikt
AU - Glas, Gerie
AU - Colpaert, Kirsten
AU - Malbrain, Manu
AU - Neto, Ary Serpa
AU - Asehnoune, Karim
AU - de Abreu, Marcello Gamma
AU - Martin-Loeches, Ignacio
AU - Pelosi, Paolo
AU - Sjöberg, Folke
AU - Binnekade, Jan M
AU - Cleffken, Berry
AU - Juffermans, Nicole P
AU - Knape, Paul
AU - Loef, Bert G
AU - Mackie, David P
AU - Enkhbaatar, Perenlei
AU - Depetris, Nadia
AU - Perner, Anders
AU - Herrero, Eva
AU - Cachafeiro, Lucia
AU - Jeschke, Marc
AU - Lipman, Jeffrey
AU - Legrand, Matthieu
AU - Horter, Johannes
AU - Lavrentieva, Athina
AU - Glas, Gerie
AU - Kazemi, Alex
AU - Guttormsen, Anne Berit
AU - Huss, Frederik
AU - Kol, Mark
AU - Wong, Helen
AU - Starr, Therese
AU - De Crop, Luc
AU - de Oliveira Filho, Wilson
AU - Manoel Silva Junior, João
AU - Grion, Cintia M C
AU - Jeschke, Marc G
AU - Burnett, Marjorie
AU - Mondrup, Frederik
AU - Ravat, Francois
AU - Fontaine, Mathieu
AU - Asehoune, Karim
AU - Floch, Renan Le
AU - Jeanne, Mathieu
AU - Bacus, Morgane
AU - Vieleers, Nadine
N1 - © The Author(s) 2021. Published by Oxford University Press.
PY - 2021
Y1 - 2021
N2 - Background: It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28).Methods: This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. Low tidal volume (V T) was defined as V T ≤ 8 mL/kg predicted body weight (PBW). Levels of positive end-expiratory pressure (PEEP) and maximum airway pressures were collected. The association between V T and VFD-28 was analyzed using a competing risk model. Ventilation settings were presented for all patients, focusing on the first day of ventilation. We also compared ventilation settings between patients with and without inhalation trauma.Results: A total of 160 patients from 28 ICUs in 16 countries were included. Low V T was used in 74% of patients, median V T size was 7.3 [interquartile range (IQR) 6.2-8.3] mL/kg PBW and did not differ between patients with and without inhalation trauma (p = 0.58). Median VFD-28 was 17 (IQR 0-26), without a difference between ventilation with low or high V T (p = 0.98). All patients were ventilated with PEEP levels ≥5 cmH2O; 80% of patients had maximum airway pressures <30 cmH2O.Conclusion: In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients, irrespective of the presence of inhalation trauma. Use of low V T was not associated with a reduction in VFD-28.Trial registration: Clinicaltrials.gov NCT02312869. Date of registration: 9 December 2014.
AB - Background: It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28).Methods: This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. Low tidal volume (V T) was defined as V T ≤ 8 mL/kg predicted body weight (PBW). Levels of positive end-expiratory pressure (PEEP) and maximum airway pressures were collected. The association between V T and VFD-28 was analyzed using a competing risk model. Ventilation settings were presented for all patients, focusing on the first day of ventilation. We also compared ventilation settings between patients with and without inhalation trauma.Results: A total of 160 patients from 28 ICUs in 16 countries were included. Low V T was used in 74% of patients, median V T size was 7.3 [interquartile range (IQR) 6.2-8.3] mL/kg PBW and did not differ between patients with and without inhalation trauma (p = 0.58). Median VFD-28 was 17 (IQR 0-26), without a difference between ventilation with low or high V T (p = 0.98). All patients were ventilated with PEEP levels ≥5 cmH2O; 80% of patients had maximum airway pressures <30 cmH2O.Conclusion: In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients, irrespective of the presence of inhalation trauma. Use of low V T was not associated with a reduction in VFD-28.Trial registration: Clinicaltrials.gov NCT02312869. Date of registration: 9 December 2014.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143991138&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34926707
U2 - https://doi.org/10.1093/burnst/tkab034
DO - https://doi.org/10.1093/burnst/tkab034
M3 - Article
C2 - 34926707
SN - 2321-3868
VL - 9
SP - 698
EP - 710
JO - Burns & trauma
JF - Burns & trauma
ER -