Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI

Kirian van der Weg; Mohamed Majidi; Joost D. E. Haeck; Jan G. P. Tijssen; Cynthia L. Green; Karel T. Koch; Wichert J. Kuijt; Mitchell W. Krucoff; Anton P. M. Gorgels; Robbert J. de Winter

doi:https://doi.org/10.1016/j.jelectrocard.2016.03.013

Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI

Kirian van der Weg, Mohamed Majidi, Joost D. E. Haeck, Jan G. P. Tijssen, Cynthia L. Green, Karel T. Koch, Wichert J. Kuijt, Mitchell W. Krucoff, Anton P. M. Gorgels, Robbert J. de Winter

Cardiology (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

We hypothesized that ventricular arrhythmia (VA) bursts during reperfusion phase are a marker of larger infarct size despite optimal epicardial and microvascular perfusion. 126 STEMI patients were studied with 24h continuous, 12-lead Holter monitoring. Myocardial blush grade (MBG) was determined and VA bursts were identified against subject-specific background VA rates in core laboratories. Delayed-enhancement cardiovascular magnetic resonance imaging was used to determine infarct size. In the group with MBG 3 no significant differences were found for baseline characteristics between burst versus no burst (102 vs. 24). In those with optimal epicardial and microvascular reperfusion (TIMI 3, stable ST-recovery, and MBG 3), VA burst was associated with larger infarct size (N=102/126; median 11.0 vs. 5.1%; p=0.004). In the event of MBG 3, VA bursts were associated with significantly larger infarct size even if optimal epicardial and microvascular reperfusion was present

Original language	English
Pages (from-to)	345-352
Journal	Journal of electrocardiology
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/j.jelectrocard.2016.03.013
Publication status	Published - 2016

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Cite this

van der Weg, K., Majidi, M., Haeck, J. D. E., Tijssen, J. G. P., Green, C. L., Koch, K. T., Kuijt, W. J., Krucoff, M. W., Gorgels, A. P. M., & de Winter, R. J. (2016). Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI. Journal of electrocardiology, 49(3), 345-352. https://doi.org/10.1016/j.jelectrocard.2016.03.013

@article{45112d6d34ae483880ea413f6f211499,

title = "Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI",

abstract = "We hypothesized that ventricular arrhythmia (VA) bursts during reperfusion phase are a marker of larger infarct size despite optimal epicardial and microvascular perfusion. 126 STEMI patients were studied with 24h continuous, 12-lead Holter monitoring. Myocardial blush grade (MBG) was determined and VA bursts were identified against subject-specific background VA rates in core laboratories. Delayed-enhancement cardiovascular magnetic resonance imaging was used to determine infarct size. In the group with MBG 3 no significant differences were found for baseline characteristics between burst versus no burst (102 vs. 24). In those with optimal epicardial and microvascular reperfusion (TIMI 3, stable ST-recovery, and MBG 3), VA burst was associated with larger infarct size (N=102/126; median 11.0 vs. 5.1%; p=0.004). In the event of MBG 3, VA bursts were associated with significantly larger infarct size even if optimal epicardial and microvascular reperfusion was present",

author = "{van der Weg}, Kirian and Mohamed Majidi and Haeck, {Joost D. E.} and Tijssen, {Jan G. P.} and Green, {Cynthia L.} and Koch, {Karel T.} and Kuijt, {Wichert J.} and Krucoff, {Mitchell W.} and Gorgels, {Anton P. M.} and {de Winter}, {Robbert J.}",

year = "2016",

doi = "https://doi.org/10.1016/j.jelectrocard.2016.03.013",

language = "English",

volume = "49",

pages = "345--352",

journal = "Journal of electrocardiology",

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T1 - Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI

AU - van der Weg, Kirian

AU - Majidi, Mohamed

AU - Haeck, Joost D. E.

AU - Tijssen, Jan G. P.

AU - Green, Cynthia L.

AU - Koch, Karel T.

AU - Kuijt, Wichert J.

AU - Krucoff, Mitchell W.

AU - Gorgels, Anton P. M.

AU - de Winter, Robbert J.

PY - 2016

Y1 - 2016

N2 - We hypothesized that ventricular arrhythmia (VA) bursts during reperfusion phase are a marker of larger infarct size despite optimal epicardial and microvascular perfusion. 126 STEMI patients were studied with 24h continuous, 12-lead Holter monitoring. Myocardial blush grade (MBG) was determined and VA bursts were identified against subject-specific background VA rates in core laboratories. Delayed-enhancement cardiovascular magnetic resonance imaging was used to determine infarct size. In the group with MBG 3 no significant differences were found for baseline characteristics between burst versus no burst (102 vs. 24). In those with optimal epicardial and microvascular reperfusion (TIMI 3, stable ST-recovery, and MBG 3), VA burst was associated with larger infarct size (N=102/126; median 11.0 vs. 5.1%; p=0.004). In the event of MBG 3, VA bursts were associated with significantly larger infarct size even if optimal epicardial and microvascular reperfusion was present

AB - We hypothesized that ventricular arrhythmia (VA) bursts during reperfusion phase are a marker of larger infarct size despite optimal epicardial and microvascular perfusion. 126 STEMI patients were studied with 24h continuous, 12-lead Holter monitoring. Myocardial blush grade (MBG) was determined and VA bursts were identified against subject-specific background VA rates in core laboratories. Delayed-enhancement cardiovascular magnetic resonance imaging was used to determine infarct size. In the group with MBG 3 no significant differences were found for baseline characteristics between burst versus no burst (102 vs. 24). In those with optimal epicardial and microvascular reperfusion (TIMI 3, stable ST-recovery, and MBG 3), VA burst was associated with larger infarct size (N=102/126; median 11.0 vs. 5.1%; p=0.004). In the event of MBG 3, VA bursts were associated with significantly larger infarct size even if optimal epicardial and microvascular reperfusion was present

U2 - https://doi.org/10.1016/j.jelectrocard.2016.03.013

DO - https://doi.org/10.1016/j.jelectrocard.2016.03.013

M3 - Article

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SN - 0022-0736

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JO - Journal of electrocardiology

JF - Journal of electrocardiology

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