Verbal fluency as a possible predictor for psychosis

H. E. Becker, D. H. Nieman, P. M. Dingemans, J. R. van de Fliert, L. de Haan, D. H. Linszen

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Abstract

Background: Neurocognitive abnormalities are prevalent in both first episode schizophrenia patients and in ultra high risk (UHR) patients. Aim: To compare verbal fluence performance at baseline in UHR in patients that did and did not make the transiton to psychosis. Method: Baseline verbal fluence performanace in UHR-patients (n=47) was compared to match first episode patients (n=69) and normal controls (n=42) Results: Verbal fluency (semantic category) score in UHR-patients did not differ significantly from the score in first episode schizophrenia patients. Both the UHR group (p <0.003) and the patient group (p <0.0001) performed significantly worse than controls. Compared to the non-transition group, the transition group performed worse on verbel fluency, semantic category (p <0.006) at baseline. Conclusions: Verbel fluency (semantic category) is disturbed in UHR-patients that make the transition to psychosis and could contribute to an improved prediction of transition to psychosis in UHR-patients. (C) 2009 Elsevier Masson SAS. All rights reserved
Original languageEnglish
Pages (from-to)105-110
JournalEuropean psychiatry
Volume25
Issue number2
DOIs
Publication statusPublished - 2010

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