Verhoogd cardiovasculair risico door glucocorticoïden

Translated title of the contribution: Increased cardiovascular risk due to glucocorticoids: how strong is the evidence?

Research output: Contribution to journalArticleProfessional

1 Citation (Scopus)


Glucocorticoids are important for treatment of (auto-)immune diseases. Prolonged use of high dose glucocorticoids increases the cardiovascular disease risk. Underlying mechanisms have not been fully elucidated but increased incidence of traditional cardiovascular risk factors and enhanced (V)LDL-cholesterol synthesis are important contributors. If and to what extent this also holds for low-dose corticosteroids (< 7.5mg prednisolone/day) is still unknown. The current evidence is based on observational studies which are often dominated by 'confounding by indication', as disease activity itself is an independent cardiovascular risk factor, and particularly patients with active disease are more likely to receive higher doses of glucocorticoids. Future studies (preferably RCT's) with disease activity data and medication use are required to solve this issue. Obviously, we must always remain critical regarding the use of glucocorticoids and aim for the lowest possible adequate dose and shortest treatment duration.
Translated title of the contributionIncreased cardiovascular risk due to glucocorticoids: how strong is the evidence?
Original languageDutch
JournalNederlands Tijdschrift voor Geneeskunde
Publication statusPublished - 8 Apr 2021


  • Adrenal Cortex Hormones/adverse effects
  • Arrhythmias, Cardiac/chemically induced
  • Cardiovascular Diseases/chemically induced
  • Dose-Response Relationship, Drug
  • Glucocorticoids/adverse effects
  • Heart Disease Risk Factors
  • Humans
  • Incidence
  • Observational Studies as Topic
  • Prednisolone/adverse effects
  • Risk Factors

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