TY - JOUR
T1 - Vertebra disc ratio as a parameter for bone marrow involvement and its application in Gaucher disease
AU - Vlieger, Erik-Jan P.
AU - Maas, Mario
AU - Akkerman, Erik M.
AU - Hollak, Carla E. M.
AU - den Heeten, Gerard J.
PY - 2002
Y1 - 2002
N2 - Objective: To establish the vertebra disc ratio (VDR), the ratio of the average T1-weighted gray value of disc L3 and intervertebral disc L3/L4, as a parameter for bone marrow involvement. To explore its value as alternative for bone marrow fat fraction measured with Dixon Quantitative Chemical Shift Imaging (Ff) in Gaucher disease (GD). Methods: Age dependency and normal value for the VDR were determined in 46 controls. The VDR in untreated GD (n = 22) and long-treated GD (7.5 years; n = 19) were compared with it. The changes in VDR in treated (n = 33) and untreated (n 8) GD were calculated. The correlation between VDR and Ff was determined. Results: Age dependency was small. The normal VDR was 1.90 +/- 0.30, both untreated GD (1.29 +/- 0.31) and long-treated GD (1.70 +/- 0.33) differed significantly from normal. Changes in treated GD were significant in the first four treatment years, in untreated GD they were not. The correlation with Ff was 0.86. Conclusions: The VDR is a useful parameter for evaluation of bone marrow of patients with GD. The VDR correlates very well with Ff, so applicability is expected in diseases in which Ff has proven to be useful
AB - Objective: To establish the vertebra disc ratio (VDR), the ratio of the average T1-weighted gray value of disc L3 and intervertebral disc L3/L4, as a parameter for bone marrow involvement. To explore its value as alternative for bone marrow fat fraction measured with Dixon Quantitative Chemical Shift Imaging (Ff) in Gaucher disease (GD). Methods: Age dependency and normal value for the VDR were determined in 46 controls. The VDR in untreated GD (n = 22) and long-treated GD (7.5 years; n = 19) were compared with it. The changes in VDR in treated (n = 33) and untreated (n 8) GD were calculated. The correlation between VDR and Ff was determined. Results: Age dependency was small. The normal VDR was 1.90 +/- 0.30, both untreated GD (1.29 +/- 0.31) and long-treated GD (1.70 +/- 0.33) differed significantly from normal. Changes in treated GD were significant in the first four treatment years, in untreated GD they were not. The correlation with Ff was 0.86. Conclusions: The VDR is a useful parameter for evaluation of bone marrow of patients with GD. The VDR correlates very well with Ff, so applicability is expected in diseases in which Ff has proven to be useful
U2 - https://doi.org/10.1097/00004728-200209000-00031
DO - https://doi.org/10.1097/00004728-200209000-00031
M3 - Article
C2 - 12439326
SN - 0363-8715
VL - 26
SP - 843
EP - 848
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
IS - 5
ER -