TY - JOUR
T1 - Visceral adipose tissue volume is associated with premature atherosclerosis in early type 2 diabetes mellitus independent of traditional risk factors
AU - Reijrink, Melanie
AU - de Boer, Stefanie A.
AU - Spoor, Daan S.
AU - Lefrandt, Joop D.
AU - Lambers Heerspink, Hiddo J.
AU - Boellaard, Ronald
AU - Greuter, Marcel J. W.
AU - Borra, Ronald J. H.
AU - Hillebrands, Jan-Luuk
AU - Slart, Riemer H. J. A.
AU - Mulder, Douwe J.
PY - 2019
Y1 - 2019
N2 - Background and aims: Type 2 diabetes mellitus (T2DM) is commonly associated with abdominal obesity, predominantly with high visceral adipose tissue (VAT), and is accompanied by premature atherosclerosis. However, the association between VAT and subcutaneous adipose tissue (SAT) with premature atherosclerosis and (i.e. arterial) inflammation is not completely understood. To provide more insight into this association, we investigated the association between arterial 18F-fluordeoxyglucose (FDG) positron emission tomography (PET) uptake, as a measure of arterial inflammation, and metabolic syndrome (MetS) markers in early T2DM patients. Methods: Forty-four patients with early T2DM, without glucose lowering medication, were studied (median age 63 [IQR 54–66] years, median BMI 30.4 [IQR 27.5–35.8]). Arterial inflammation was quantified using glucose corrected maximum standardized uptake value (SUVmax) FDG of the aorta, carotid, iliac, and femoral arteries, and corrected for background activity (blood pool) as target-to-background ratio (meanTBR). VAT and SAT volumes (cm3) were automatically segmented using computed tomography (CT) between levels L1-L5. Non-alcoholic fatty liver disease (NAFLD) was assessed by liver function test and CT. Results: VAT volume, but not SAT volume, correlated with meanTBR (r = 0.325, p = 0.031). Linear regression models showed a significant association, even after sequential adjustment for potentially influencing MetS components. Interaction term VAT volume * sex and additional components including HbA1c, insulin resistance, NAFLD, adiponectin, leptin, and C- reactive protein (CRP) did not change the independent association between VAT volume and meanTBR. Conclusions: CT-assessed VAT volume is positively associated with FDG-PET assessed arterial inflammation, independently of factors thought to potentially mediate these effects. These findings suggest that VAT in contrast to SAT is linked to early atherosclerotic changes in T2DM patients.
AB - Background and aims: Type 2 diabetes mellitus (T2DM) is commonly associated with abdominal obesity, predominantly with high visceral adipose tissue (VAT), and is accompanied by premature atherosclerosis. However, the association between VAT and subcutaneous adipose tissue (SAT) with premature atherosclerosis and (i.e. arterial) inflammation is not completely understood. To provide more insight into this association, we investigated the association between arterial 18F-fluordeoxyglucose (FDG) positron emission tomography (PET) uptake, as a measure of arterial inflammation, and metabolic syndrome (MetS) markers in early T2DM patients. Methods: Forty-four patients with early T2DM, without glucose lowering medication, were studied (median age 63 [IQR 54–66] years, median BMI 30.4 [IQR 27.5–35.8]). Arterial inflammation was quantified using glucose corrected maximum standardized uptake value (SUVmax) FDG of the aorta, carotid, iliac, and femoral arteries, and corrected for background activity (blood pool) as target-to-background ratio (meanTBR). VAT and SAT volumes (cm3) were automatically segmented using computed tomography (CT) between levels L1-L5. Non-alcoholic fatty liver disease (NAFLD) was assessed by liver function test and CT. Results: VAT volume, but not SAT volume, correlated with meanTBR (r = 0.325, p = 0.031). Linear regression models showed a significant association, even after sequential adjustment for potentially influencing MetS components. Interaction term VAT volume * sex and additional components including HbA1c, insulin resistance, NAFLD, adiponectin, leptin, and C- reactive protein (CRP) did not change the independent association between VAT volume and meanTBR. Conclusions: CT-assessed VAT volume is positively associated with FDG-PET assessed arterial inflammation, independently of factors thought to potentially mediate these effects. These findings suggest that VAT in contrast to SAT is linked to early atherosclerotic changes in T2DM patients.
KW - Abdominal visceral adipose tissue
KW - Arterial inflammation
KW - Cardiovascular risk
KW - FDG-PET
KW - Type 2 diabetes mellitus
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072977316&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31604171
U2 - https://doi.org/10.1016/j.atherosclerosis.2019.09.016
DO - https://doi.org/10.1016/j.atherosclerosis.2019.09.016
M3 - Article
C2 - 31604171
SN - 0021-9150
VL - 290
SP - 87
EP - 93
JO - Atherosclerosis
JF - Atherosclerosis
ER -